Phosphatidyl-N-methylethanolamine N-methyltransferase

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In enzymology, a phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine $\rightleftharpoons$ S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine

Thus, the two substrates of this enzyme are S-adenosyl methionine and phosphatidyl-N-methylethanolamine, whereas its two products are S-adenosylhomocysteine and phosphatidyl-N-dimethylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase. Other names in common use include phosphatidylmonomethylethanolamine methyltransferase, methyltransferase II, phospholipid methyltransferase, PLMT, phosphatidyl-N-methylethanolamine methyltransferase, phosphatidyl-N-monomethylethanolamine methyltransferase, phosphatidylethanolamine methyltransferase I, and phosphatidylmonomethylethanolamine methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.

[edit] References

IUBMB entry for 2.1.1.71
BRENDA references for 2.1.1.71 (Recommended.)
PubMed references for 2.1.1.71
PubMed Central references for 2.1.1.71
Google Scholar references for 2.1.1.71
Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J (1978). "Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine". Proc. Natl. Acad. Sci. U. S. A. 75: 1718–21. doi:10.1073/pnas.75.4.1718. PMID 25437.
Schneider WJ, Vance DE (1979). "Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities". J. Biol. Chem. 254: 3886–91. PMID 438165.