Phosphatidate phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a phosphatidate phosphatase (EC 3.1.3.4) is an enzyme that catalyzes the chemical reaction

a 3-sn-phosphatidate + H₂O a 1,2-diacyl-sn-glycerol + phosphate

Thus, the two substrates of this enzyme are 3-sn-phosphatidate and H₂O, whereas its two products are 1,2-diacyl-sn-glycerol and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 3-sn-phosphatidate phosphohydrolase. Other names in common use include phosphatic acid phosphatase, acid phosphatidyl phosphatase, and phosphatic acid phosphohydrolase. This enzyme participates in 4 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, ether lipid metabolism, and sphingolipid metabolism.

[edit] References

• IUBMB entry for 3.1.3.4
• BRENDA references for 3.1.3.4 (Recommended.)
• PubMed references for 3.1.3.4
• PubMed Central references for 3.1.3.4
• Google Scholar references for 3.1.3.4
• Smith SW, Weiss SB and Kennedy EP (1957). "The enzymatic dephosphorylation of phosphatidic acids". J. Biol. Chem. 228: 915–922. 

[edit] External links

The CAS registry number for this enzyme class is 9025-77-8.

• IUBMB entry for 3.1.3.4

• KEGG entry for 3.1.3.4

• BRENDA entry for 3.1.3.4

• NiceZyme view of 3.1.3.4

• EC2PDB: PDB structures for 3.1.3.4

• PRIAM entry for 3.1.3.4

• PUMA2 entry for 3.1.3.4

• IntEnz: Integrated Enzyme entry for 3.1.3.4

• MetaCyc entry for 3.1.3.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008195: phosphatidate phosphatase

• AMIGO entry for GO code 0008195: phosphatidate phosphatase