Phorbol-diester hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a phorbol-diester hydrolase (EC 3.1.1.51) is an enzyme that catalyzes the chemical reaction

phorbol 12,13-dibutanoate + H₂O phorbol 13-butanoate + butanoate

Thus, the two substrates of this enzyme are phorbol 12,13-dibutanoate and H₂O, whereas its two products are phorbol 13-butanoate and butanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 12,13-diacylphorbate 12-acylhydrolase. Other names in common use include diacylphorbate 12-hydrolase, diacylphorbate 12-hydrolase, phorbol-12,13-diester 12-ester hydrolase, and PDEH.

[edit] References

• IUBMB entry for 3.1.1.51
• BRENDA references for 3.1.1.51 (Recommended.)
• PubMed references for 3.1.1.51
• PubMed Central references for 3.1.1.51
• Google Scholar references for 3.1.1.51
• Shoyab M, Warren TC, Todaro GJ (1981). "Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver". J. Biol. Chem. 256: 12529–34. PMID 6946062. 

[edit] External links

The CAS registry number for this enzyme class is 81181-74-0.

• IUBMB entry for 3.1.1.51

• KEGG entry for 3.1.1.51

• BRENDA entry for 3.1.1.51

• NiceZyme view of 3.1.1.51

• EC2PDB: PDB structures for 3.1.1.51

• PRIAM entry for 3.1.1.51

• PUMA2 entry for 3.1.1.51

• IntEnz: Integrated Enzyme entry for 3.1.1.51

• MetaCyc entry for 3.1.1.51

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050181: phorbol-diester hydrolase

• AMIGO entry for GO code 0050181: phorbol-diester hydrolase