PHLPPL

From Wikipedia, the free encyclopedia

PH domain and leucine rich repeat protein phosphatase-like

Identifiers

PHLPPL; KIAA0931

External IDs

Gene ontology
Molecular Function:	• catalytic activity • phosphoprotein phosphatase activity • protein binding • hydrolase activity • manganese ion binding • metal ion binding
Cellular Component:	• cytoplasm

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015020 (mRNA)
NP_055835 (protein)

XM_001003810 (mRNA)
XP_001003810 (protein)

Location

Chr 16: 70.23 - 70.32 Mb

Chr 8: 112.76 - 112.83 Mb

Pubmed search

[1]

[2]

PH domain and leucine rich repeat protein phosphatase-like, also known as PHLPPL, is a human gene.^[1]

[edit] References

^ Entrez Gene: PHLPPL PH domain and leucine rich repeat protein phosphatase-like.

[edit] Further reading

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63-70. PMID 10231032.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988-94. doi:10.1038/nature03187. PMID 15616553.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.". Mol. Cell 25 (6): 917-31. doi:10.1016/j.molcel.2007.02.017. PMID 17386267.