Philanthotoxin

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delta-Philathotoxin
IUPAC name N-[(2S)-1-[4-[3-(3-Aminopropylamino)propylamino]butylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide
Identifiers
CAS number
PubChem 115201
SMILES CCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NCCCCNCCCNCCCN
Properties
Molecular formula C23H41N5O3
Molar mass 435.603 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Philantothoxins are components of the venom of Egyptian solitary wasp Philanthus triangulum F and four toxins are distinguished (alpha, beta, gamma, delta) among which delta-philanthotoxin (dPTX) is most effective to block glutamate receptors[1] and especially those quisqualate-sensitive, that isAMPA receptor[2]. It has later been shown that dPTX targets calcium permeable AMPA receptor and kainate receptor but not NMDA receptor.[3]

[edit] References

  1. ^ Piek T (1982) Comp Biochem Physiol C 72:311-315
  2. ^ Clark RB, Donaldson PL, Gration KAF, Lambert JJ, Piek T, Ramsey RL, Spanjer, Usheerwood PNR (1982) Brain Research 241:105-114
  3. ^ Jones MJ, Anis NA, Lodge D (1990) Br J Pharmacol 101(4):968-970


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