Talk:Phenelzine

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[edit] The original Nardil?

Why isn't another company making the original Nardil? The action of phenelzine today is the same as it was when I first started taking it about 1985. At that time phenelzine was thought to be a dangerous drug that could raise the blood pressure and cause strokes. Phenelzine does cause a mild increase in dopamine and its first break down product, nor-epinephrine. We used nor-epinephrine for the treatment of shock when it first became available. The vaso-constrictor effect of nor-epinephrine may be the reason why phenelzine is so effective in treatment and prevention of migraine type headaches. However, not enough hypertensive action of nor-epinephrine occurs in blood pressure readings when given orally to cause the slightest increase in blood pressure. This year I am taking an ACE inhibitor that lowers the blood pressure very successfully and the phenelzine has no apparent effect on blood pressure. The primary action of phenelzine is, as suggested, obviously to prevent the destruction of enkephalins. Since I have taken phenelzine 30 mg. od my headaches have completely stopped. I can stand extreme pain without passing out. Taken orally it passes through blood brain barrier in ten minutes and stops the vomiting of migraine headaches that fast. I have used this drug for itching in my mother and kept her alive with it for an additional five years. Finally, the action of nor-epinephrine not only increases attention slightly, it improves steadiness of writing and reduces appetite. It has a great future for it if people are allowed to use it for reducing weight. Thomas Lee Tayor, MD (retired) 116 Jones Drive, Dunn, NC 28334-2911. tltaylor@dockpoint.net.