Phenylpyruvate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a phenylpyruvate decarboxylase (EC 4.1.1.43) is an enzyme that catalyzes the chemical reaction

phenylpyruvate phenylacetaldehyde + CO₂

Hence, this enzyme has one substrate, phenylpyruvate, and two products, phenylacetaldehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming). This enzyme is also called phenylpyruvate carboxy-lyase. This enzyme participates in phenylalanine and tryptophan metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2NXW.

[edit] References

• IUBMB entry for 4.1.1.43
• BRENDA references for 4.1.1.43 (Recommended.)
• PubMed references for 4.1.1.43
• PubMed Central references for 4.1.1.43
• Google Scholar references for 4.1.1.43
• Asakawa T, Wada H, Yamano T (1968). "Enzymatic conversion of phenylpyruvate to phenylacetate". Biochim. Biophys. Acta. 170: 375–91. PMID 4303395. 

[edit] External links

The CAS registry number for this enzyme class is 37289-45-5.

• IUBMB entry for 4.1.1.43

• KEGG entry for 4.1.1.43

• BRENDA entry for 4.1.1.43

• NiceZyme view of 4.1.1.43

• EC2PDB: PDB structures for 4.1.1.43

• PRIAM entry for 4.1.1.43

• PUMA2 entry for 4.1.1.43

• IntEnz: Integrated Enzyme entry for 4.1.1.43

• MetaCyc entry for 4.1.1.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050177: phenylpyruvate decarboxylase

• AMIGO entry for GO code 0050177: phenylpyruvate decarboxylase