Phenylacetyl-CoA dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a phenylacetyl-CoA dehydrogenase (EC 1.17.5.1) is an enzyme that catalyzes the chemical reaction

phenylacetyl-CoA + H₂O + 2 quinone phenylglyoxylyl-CoA + 2 quinol

The 3 substrates of this enzyme are phenylacetyl-CoA, H₂O, and quinone, whereas its two products are phenylglyoxylyl-CoA and quinol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with a quinone or similar compound as acceptor. The systematic name of this enzyme class is phenylacetyl-CoA:quinone oxidoreductase. This enzyme is also called phenylacetyl-CoA:acceptor oxidoreductase.

[edit] References

• IUBMB entry for 1.17.5.1
• BRENDA references for 1.17.5.1 (Recommended.)
• PubMed references for 1.17.5.1
• PubMed Central references for 1.17.5.1
• Google Scholar references for 1.17.5.1
• Rhee SK, Fuchs G (1999). "Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum-iron-sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica". Eur. J. Biochem. 262: 507–15. doi:10.1046/j.1432-1327.1999.00399.x. PMID 10336636. 
• Schneider S, Fuchs G (1998). "Phenylacetyl-CoA:acceptor oxidoreductase, a new alpha-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica". Arch. Microbiol. 169: 509–16. doi:10.1007/s002030050604. PMID 9575237. 

[edit] External links

• IUBMB entry for 1.17.5.1

• KEGG entry for 1.17.5.1

• BRENDA entry for 1.17.5.1

• NiceZyme view of 1.17.5.1

• EC2PDB: PDB structures for 1.17.5.1

• PRIAM entry for 1.17.5.1

• PUMA2 entry for 1.17.5.1

• IntEnz: Integrated Enzyme entry for 1.17.5.1

• MetaCyc entry for 1.17.5.1

• Atomic-resolution structures of enzymes belonging to this class