PHACTR3

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Phosphatase and actin regulator 3
Identifiers
Symbol(s) PHACTR3; C20orf101; H17739; MGC117178; SCAPIN1
External IDs OMIM: 608725 MGI: 1921439 HomoloGene: 14482
Orthologs
Human Mouse
Entrez 116154 74189
Ensembl ENSG00000087495 ENSMUSG00000027525
Uniprot Q96KR7 Q6KCA9
Refseq NM_080672 (mRNA)
NP_542403 (protein)		 NM_001007154 (mRNA)
NP_001007155 (protein)
Location Chr 20: 57.59 - 57.86 Mb Chr 2: 178.07 - 178.27 Mb
Pubmed search [1] [2]

Phosphatase and actin regulator 3, also known as PHACTR3, is a human gene.[1]

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: PHACTR3 phosphatase and actin regulator 3.

[edit] Further reading

  • Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human.". Cytogenet. Genome Res. 115 (1): 23–9. doi:10.1159/000094797. PMID 16974080. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Allen PB, Greenfield AT, Svenningsson P, et al. (2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7187–92. doi:10.1073/pnas.0401673101. PMID 15107502. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Sagara J, Higuchi T, Hattori Y, et al. (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure.". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
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