PGLYRP2

From Wikipedia, the free encyclopedia

Peptidoglycan recognition protein 2

Identifiers

PGLYRP2; HMFT0141; PGLYRPL; PGRP-L; PGRPL; TAGL-like; tagL; tagL-alpha; tagl-beta

External IDs

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • N-acetylmuramoyl-L-alanine amidase activity • peptidoglycan receptor activity • hydrolase activity • metal ion binding
Cellular Component:	• intracellular • membrane
Biological Process:	• peptide amidation • peptidoglycan catabolic process • detection of bacterium • innate immune response • defense response to Gram-positive bacterium

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_052890 (mRNA)
NP_443122 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 19: 15.44 - 15.45 Mb

n/a

Pubmed search

[1]

n/a

Peptidoglycan recognition protein 2, also known as PGLYRP2, is a human gene.^[1]

Peptidoglycan recognition proteins, such as PGRPL, are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PGLYRP2 peptidoglycan recognition protein 2.

[edit] Further reading

De Pauw P, Neyt C, Vanderwinkel E, et al. (1995). "Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography.". Protein Expr. Purif. 6 (3): 371-8. PMID 7663175.
Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.". Science 293 (5527): 104-11. doi:10.1126/science.1060310. PMID 11441184.
Liu C, Xu Z, Gupta D, Dziarski R (2001). "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.". J. Biol. Chem. 276 (37): 34686-94. doi:10.1074/jbc.M105566200. PMID 11461926.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089-94. doi:10.1073/pnas.241522398. PMID 11752456.
Kibardin AV, Mirkina II, Zakeeva IR, et al. (2003). "[Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells]". Genetika 39 (2): 244-9. PMID 12669421.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660-6. doi:10.1038/nbt827. PMID 12754519.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Wang ZM, Li X, Cocklin RR, et al. (2004). "Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.". J. Biol. Chem. 278 (49): 49044-52. doi:10.1074/jbc.M307758200. PMID 14506276.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.". Oncogene 23 (35): 5901-11. doi:10.1038/sj.onc.1207782. PMID 15221005.
Xu M, Wang Z, Locksley RM (2004). "Innate immune responses in peptidoglycan recognition protein L-deficient mice.". Mol. Cell. Biol. 24 (18): 7949-57. doi:10.1128/MCB.24.18.7949-7957.2004. PMID 15340057.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Zhang Y, van der Fits L, Voerman JS, et al. (2005). "Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2.". Biochim. Biophys. Acta 1752 (1): 34-46. doi:10.1016/j.bbapap.2005.07.001. PMID 16054449.
Wang H, Gupta D, Li X, Dziarski R (2005). "Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway.". Infect. Immun. 73 (11): 7216-25. doi:10.1128/IAI.73.11.7216-7225.2005. PMID 16239516.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Li X, Wang S, Wang H, Gupta D (2006). "Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors.". J. Biol. Chem. 281 (30): 20738-48. doi:10.1074/jbc.M601017200. PMID 16714290.