PGLYRP1

From Wikipedia, the free encyclopedia

Peptidoglycan recognition protein 1

PDB rendering based on 1yck.

Available structures: 1yck

Identifiers

Symbol(s)

PGLYRP1; MGC126894; MGC126896; PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L

External IDs

OMIM: 604963 MGI: 1345092 HomoloGene: 74539

Gene ontology
Molecular Function:	• protein binding • bacterial binding • N-acetylmuramoyl-L-alanine amidase activity • peptidoglycan receptor activity
Cellular Component:	• extracellular region
Biological Process:	• peptidoglycan catabolic process • detection of bacterium • innate immune response • defense response to Gram-positive bacterium

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005091 (mRNA)
NP_005082 (protein)

XM_991298 (mRNA)
XP_996392 (protein)

Location

Chr 19: 51.21 - 51.22 Mb

Chr 7: 18.04 - 18.05 Mb

Pubmed search

[1]

[2]

Peptidoglycan recognition protein 1, also known as PGLYRP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PGLYRP1 peptidoglycan recognition protein 1.

[edit] Further reading

Cho JH, Fraser IP, Fukase K, et al. (2005). "Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.". Blood 106 (7): 2551–8. doi:10.1182/blood-2005-02-0530. PMID 15956276.
Guan R, Wang Q, Sundberg EJ, Mariuzza RA (2005). "Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.". J. Mol. Biol. 347 (4): 683–91. doi:10.1016/j.jmb.2005.01.070. PMID 15769462.
Guan R, Roychowdhury A, Ember B, et al. (2005). "Structural basis for peptidoglycan binding by peptidoglycan recognition proteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (49): 17168–73. doi:10.1073/pnas.0407856101. PMID 15572450.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Guan R, Malchiodi EL, Wang Q, et al. (2004). "Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha.". J. Biol. Chem. 279 (30): 31873–82. doi:10.1074/jbc.M404920200. PMID 15140887.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Sashchenko LP, Dukhanina EA, Yashin DV, et al. (2004). "Peptidoglycan recognition protein tag7 forms a cytotoxic complex with heat shock protein 70 in solution and in lymphocytes.". J. Biol. Chem. 279 (3): 2117–24. doi:10.1074/jbc.M307513200. PMID 14585845.
Wang ZM, Li X, Cocklin RR, et al. (2004). "Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.". J. Biol. Chem. 278 (49): 49044–52. doi:10.1074/jbc.M307758200. PMID 14506276.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Kibardin AV, Mirkina II, Zakeeva IR, et al. (2003). "[Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells]". Genetika 39 (2): 244–9. PMID 12669421.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu C, Xu Z, Gupta D, Dziarski R (2001). "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.". J. Biol. Chem. 276 (37): 34686–94. doi:10.1074/jbc.M105566200. PMID 11461926.
Kang D, Liu G, Lundström A, et al. (1998). "A peptidoglycan recognition protein in innate immunity conserved from insects to humans.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10078–82. PMID 9707603.