PFKFB1

From Wikipedia, the free encyclopedia

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

PDB rendering based on 1c7z.

Available structures: 1c7z, 1c80, 1c81, 1fbt, 1k6m, 1tip

Identifiers

Symbol(s)

PFKFB1; F6PK; HL2K; MGC116715; MGC116717; PFRX

External IDs

OMIM: 311790 MGI: 107816 HomoloGene: 68267

Gene ontology
Molecular Function:	• nucleotide binding • 6-phosphofructo-2-kinase activity • fructose-2,6-bisphosphate 2-phosphatase activity • ATP binding • kinase activity • transferase activity • hydrolase activity • identical protein binding
Cellular Component:	• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
Biological Process:	• fructose 2,6-bisphosphate metabolic process • gluconeogenesis • glycolysis • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002625 (mRNA)
NP_002616 (protein)

XM_980818 (mRNA)
XP_985912 (protein)

Location

Chr X: 54.98 - 55.04 Mb

Chr X: 145.93 - 145.98 Mb

Pubmed search

[1]

[2]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, also known as PFKFB1, is a human gene.^[1]

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.^[1]

[edit] References

^ ^a ^b Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1.

[edit] Further reading

Lange AJ, Pilkis SJ (1990). "Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.". Nucleic Acids Res. 18 (12): 3652. PMID 2163524.
Marker AJ, Colosia AD, Tauler A, et al. (1989). "Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression.". J. Biol. Chem. 264 (12): 7000–4. PMID 2540168.
Algaier J, Uyeda K (1988). "Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.". Biochem. Biophys. Res. Commun. 153 (1): 328–33. PMID 2837207.
Batra RS, Hatchwell E, Rider S, et al. (1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21.". Genomics 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.
Lee YH, Li Y, Uyeda K, Hasemann CA (2003). "Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.". J. Biol. Chem. 278 (1): 523–30. doi:10.1074/jbc.M209105200. PMID 12379646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.