PFDN5

From Wikipedia, the free encyclopedia

Prefoldin subunit 5

Identifiers

PFDN5; MGC5329; MGC71907; MM-1; MM1; PFD5

External IDs

OMIM: 604899 MGI: 1928753 HomoloGene: 1972

Gene ontology
Molecular Function:	• transcription corepressor activity • unfolded protein binding
Cellular Component:	• nucleus • cytoplasm • prefoldin complex
Biological Process:	• regulation of transcription, DNA-dependent • protein folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002624 (mRNA)
NP_002615 (protein)

NM_020031 (mRNA)
NP_064415 (protein)

Location

Chr 12: 51.98 - 51.98 Mb

n/a

Pubmed search

[1]

[2]

Prefoldin subunit 5, also known as PFDN5, is a human gene.^[1]

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: PFDN5 prefoldin subunit 5.

[edit] Further reading

Vainberg IE, Lewis SA, Rommelaere H, et al. (1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.". Cell 93 (5): 863–73. PMID 9630229.
Mori K, Maeda Y, Kitaura H, et al. (1998). "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.". J. Biol. Chem. 273 (45): 29794–800. PMID 9792694.
Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins.". J. Cell Biol. 145 (2): 265–77. PMID 10209023.
Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface.". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082.
Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families.". J. Biol. Chem. 276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID 11535601.
Fujioka Y, Taira T, Maeda Y, et al. (2002). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer.". J. Biol. Chem. 276 (48): 45137–44. doi:10.1074/jbc.M106127200. PMID 11567024.
Watanabe K, Ozaki T, Nakagawa T, et al. (2002). "Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function.". J. Biol. Chem. 277 (17): 15113–23. doi:10.1074/jbc.M111281200. PMID 11844794.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding.". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
Hagio Y, Kimura Y, Taira T, et al. (2006). "Distinct localizations and repression activities of MM-1 isoforms toward c-Myc.". J. Cell. Biochem. 97 (1): 145–55. doi:10.1002/jcb.20619. PMID 16173081.