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| Pestivirus internal ribosome entry site (IRES) |
 |
| Type: |
Cis-reg; IRES; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
249.1 nucleotides |
| Avg identity: |
80% |
|
This family represents the internal ribosome entry site (IRES) of the the pestiviruses. The pestivirus IRES allows cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[1] The classical swine fever virus UTR describedappears to be longer at the 5' end than other pestivirus UTRs.[1] This family represents the conserved core.
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