Talk:Peroxisome
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[edit] first line / definition
It is not wise to begin this basic cell biol article with a teleological definition that might even be incorrect - apart from being teleological: ("Peroxisomes are ubiquitous organelles in eukaryotes that function to rid the cell of toxic substances.". ) I will change this .. (sb tell me how to binde tildes on my computer ..) sdot
Done .. i also do not like the functions part of the article; is somehow suggests that a peroxisome is a bag of antioxidant enzymes; much of the oxygen stress that peroxisomes "rid the cell of" is actually created in peroxisomes by oxidases.
The diagram shows a "Crystalline Core", but there is no mention of it anywhere in the text. There should be. Dougher 01:19, 2 November 2006 (UTC)
Added a diagram as requested. I'm not a specialist on the subject so someone should verify that the diagram is correct. — Agateller 06:04, 19 January 2006 (UTC)
The first figure and the text disagree. The text states "They have a single membrane that separates their contents from the cytosol" but the picture clearly shows a lipid bilayer. One of these has to be wrong.
- A single membrane is a lipid bilayer. There's no contradiction there.
What about the free radicals that the peroxisomes nuetralize?
Honestly I think that the proposed role of a peroxisome to get rid of reactive oxygen species (ROS) is a great misunderstanding in the field. To my limited knowledge no mechanisms exist to transport ROS specifically to peroxisomes. ROS in many comparments are very dangerous, but they are taken care of by a panoply of local mechanisms including the SOD and peroxidase.
In my view the role of peroxisomes is to compartmentalize many processes that require the presence of ROS especially H2o2 to the peroxisomes and thereby protect other cell compartments from the deleterious effects of ROS. Many of these steps are indeed linked to various aspects of the lipid metabolism..
Also one should make clear that peroxisomes are not held endosymbiotic organelles
by the majority of scientists. So the parargraph should be changed to reflect this. So it should first be stated that they can form de novo from ER vesicles (dependent on PPAR nuclear receptors). That they do not have a genome of their own, and that their proteome shares similarity to the ER.
The endosymbiotic story should be kept as a view held by a small minority of scientists relying on primarily morphological evidence. —Preceding unsigned comment added by 193.6.169.176 (talk) 14:20, 4 December 2007 (UTC)
[edit] Merger: 'Perioxisomes'
Perioxisomes currently reads as follows:
- Perioxisomes are organelles containing peroxide enzymes and perform many differentiating tasks, including breaking down fatty acids. Perioxisomes are found mainly in the liver and the kidneys, the organs primarily responsible for breaking down and excreting toxic chemicals.
- Peroxisome is an organelle in all animal and many plant cells that carries out oxidation reactions, some of which produce the toxic compound hydrogen peroxide (H2O2). Peroxisomes contain the enzyme catalase, which catalyzes the breakdown of toxic H2O2 to water and O2.
This was created as a seperate article based on a misspelling of the title. If nobody opposes merging the articles, I'll change Perioxisomes into a redirect here and the text from it will still be available on this talk page if anyone wants to incorporate it into the main article. Some of it appears to contradict what is said here (found in 'all eukaryotic cells' vs 'all animal and many plant cells'). The claim that they are 'found mainly in the liver and the kidneys' may or may not be true (of animals with these organs at least) but warrants investigation as it's not mentioned in this article.--Eloil 04:15, 25 March 2007 (UTC)
[edit] Formula problem
I'm not an expert here, so I'll leave this to someone else to change, but, for the formula:
H2O2 + R'H12 -> R' + 2H2O
should not this be:
H2O2 + R'(H1)2 -> R' + 2H2O
The formula as it is in the article, I don't understand; perhaps I am just ignorant to something.
Cheers,
Kevin
70.52.217.23 07:46, 31 October 2007 (UTC)
[edit] Vesicular transport?
I was doing some studying for a university cellbiology exam, and molecular biology of the cell 4th edition claims that peroxisomes are part of the transmembrane transport, rather than the vesicular transport. Just thought it was worth mentioning here.
Regards,
Rogier
—Preceding unsigned comment added by Rogier P (talk • contribs) 14:53, 31 May 2008 (UTC)
