Talk:Perforin
From Wikipedia, the free encyclopedia
 |
This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme. |
||
| Start | This article has been rated as Start-Class on the assessment scale. |
||
| Low | This article is on a subject of Low-importance within molecular and cellular biology. | ||
|
Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need. |
|||
The picture shown is for complement-mediated lysis, not perforin. Should it be changed? Wedgeoli 15:55, 11 December 2006 (UTC)
Yeah, that picture shouldn't be up there. Taking it down. —The preceding unsigned comment was added by 74.73.63.209 (talk) 04:58:44, August 19, 2007 (UTC)
Hi - the picture is intended to illustrate the fold of the MACPF domain, which is the lytic part of perforin (perforin also contains an EGF and a C2 domain, the latter domain is probaby positioned in a similar fashion to the beta-prism domain of Plu-MACPF). Complement proteins such as C6-C9 also have the same MACPF domain type as their lytic centre - hence this type of picture could be used to illustrate both families. I therefore feel that the picture is useful to illustrate the perforin page - it obviously would be better to shoulw a perforin structure, but unfortunately that as not been solved yet! Jcwhizz 15:57, 20 September 2007 (UTC)
