Perisinusoidal

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Perisinusodial Space of Disse

In liver: The narrow space between a plate of hepatocytes and sinusoidal lining cells. Hepatocytes do not come into contact with the bloodstream, instead, the space of Disse acts as an intermediate compartment between them. Occasionally, nonmyelinated nerve fibers and Ito cells (also known as Stellate cells) have been noted in this space. Phatogenesis: monocyte chemotactic protein 1 (MCP-1) release from Ito cells (stimulated by TNF-alpha) can lead to production of myofibroblast and production of ectracellular matrix, thus increasing resistance in the sinusoids.