Pentagastrin
From Wikipedia, the free encyclopedia
 |
|
|
Pentagastrin
|
|
| Systematic (IUPAC) name | |
| 4-(1-carbamoyl-2-phenyl-ethyl)amino-3-[2-[3-(1H-indol-3-yl)-2- [3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino- 4-methylsulfanyl-butanoyl]amino-4-oxo-butanoic acid | |
| Identifiers | |
| CAS number | |
| ATC code | V04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C37H49N7O9S |
| Mol. mass | 767.893 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 10 minutes or less |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.
Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it causes panic attacks.
Pentagstrin's IUPAC chemical name is "L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl".
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
