Pennsylvania Route 642
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| PA Route 642 |
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| Length: | 20 mi[1] (32 km) | ||||||||||||
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| Formed: | 1952 | ||||||||||||
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| Counties: | Union, Northumberland, Montour, Columbia | ||||||||||||
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Pennsylvania Route 642 is an 20 mile long state highway located in Union, Northumberland, Montour, and Columbia counties in Pennsylvania. The western terminus is at US 15 in Kelly Twp. The eastern terminus is at PA 254 in Madison Twp.

