Pennsylvania Route 381
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| PA Route 381 |
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| Length: | 48 mi[1] (77 km) | ||||||||||||
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| Formed: | 1961 | ||||||||||||
| South end: | West Virginia state line near Elliottsville | ||||||||||||
| Major junctions: |
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| North end: | |||||||||||||
| Counties: | Fayette, Westmoreland | ||||||||||||
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Pennsylvania Route 381 is an 48 mile long state highway located in Fayette, and Westmoreland counties in Pennsylvania. The southern terminus is the West Virginia state line near Elliottsville. The northern terminus is at US 30 near Ligonier.

