Pennsylvania Route 221
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| PA Route 221 |
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| Length: | 30 mi[1] (48 km) | ||||||||||||
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| Formed: | 1936 | ||||||||||||
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| North end: | |||||||||||||
| Counties: | Greene, Washington County | ||||||||||||
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Pennsylvania Route 221 is an 30 mile long state highway located in Greene and Washington counties in Pennsylvania. The southern terminus is at PA 188 near Jefferson. The northern terminus is at PA 231 in Acheson.

