PECI (gene)

From Wikipedia, the free encyclopedia

Peroxisomal D3,D2-enoyl-CoA isomerase

PDB rendering based on 2cqu.

Available structures: 2cqu, 2f6q

Identifiers

Symbol(s)

PECI; ACBD2; DRS1; HCA88; dJ1013A10.3

External IDs

OMIM: 608024 MGI: 1346064 HomoloGene: 38145

Gene ontology
Molecular Function:	• acyl-CoA binding • dodecenoyl-CoA delta-isomerase activity • binding • isomerase activity
Cellular Component:	• mitochondrion • peroxisome
Biological Process:	• fatty acid metabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006117 (mRNA)
NP_006108 (protein)

NM_011868 (mRNA)
NP_035998 (protein)

Location

Chr 6: 4.06 - 4.08 Mb

Chr 13: 34.99 - 35 Mb

Pubmed search

[1]

[2]

Peroxisomal D3,D2-enoyl-CoA isomerase, also known as PECI, is a human gene.^[1]

PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Suk K, Kim YH, Hwang DY, et al. (1999). "Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor.". Biochim. Biophys. Acta 1454 (1): 126–31. PMID 10354522.
Geisbrecht BV, Zhang D, Schulz H, Gould SJ (1999). "Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes.". J. Biol. Chem. 274 (31): 21797–803. PMID 10419495.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. PMID 10508479.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467.
Janssen U, Stoffel W (2002). "Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse.". J. Biol. Chem. 277 (22): 19579–84. doi:10.1074/jbc.M110993200. PMID 11916962.
Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.". J. Immunol. 169 (2): 1102–9. PMID 12097419.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Feng X, Chuhjo T, Sugimori C, et al. (2004). "Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells.". Blood 104 (8): 2425–31. doi:10.1182/blood-2004-05-1839. PMID 15217832.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.