PEA15

From Wikipedia, the free encyclopedia

Phosphoprotein enriched in astrocytes 15

PDB rendering based on 1n3k.

Available structures: 1n3k

Identifiers

Symbol(s)

PEA15; MAT1; PED; HMAT1; HUMMAT1H; MAT1H; PEA-15

External IDs

OMIM: 603434 MGI: 104799 HomoloGene: 7884

Gene ontology
Molecular Function:	• sugar:hydrogen ion symporter activity • protein binding
Cellular Component:	• microtubule associated complex
Biological Process:	• transport • anti-apoptosis • regulation of apoptosis • negative regulation of glucose import

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003768 (mRNA)
NP_003759 (protein)

NM_011063 (mRNA)
NP_035193 (protein)

Location

Chr 1: 158.44 - 158.45 Mb

Chr 1: 174.03 - 174.04 Mb

Pubmed search

[1]

[2]

Phosphoprotein enriched in astrocytes 15, also known as PEA15, is a human gene.^[1]

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15.

[edit] Further reading

Araujo H, Danziger N, Cordier J, et al. (1993). "Characterization of PEA-15, a major substrate for protein kinase C in astrocytes.". J. Biol. Chem. 268 (8): 5911-20. PMID 8449955.
Estellés A, Yokoyama M, Nothias F, et al. (1996). "The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human.". J. Biol. Chem. 271 (25): 14800-6. PMID 8662970.
Hwang S, Kuo WL, Cochran JF, et al. (1997). "Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers.". Genomics 42 (3): 540-2. PMID 9205133.
Condorelli G, Vigliotta G, Iavarone C, et al. (1998). "PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.". EMBO J. 17 (14): 3858-66. doi:10.1093/emboj/17.14.3858. PMID 9670003.
Kubes M, Cordier J, Glowinski J, et al. (1998). "Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro.". J. Neurochem. 71 (3): 1307-14. PMID 9721757.
Condorelli G, Vigliotta G, Cafieri A, et al. (1999). "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis.". Oncogene 18 (31): 4409-15. doi:10.1038/sj.onc.1202831. PMID 10442631.
Kitsberg D, Formstecher E, Fauquet M, et al. (1999). "Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis.". J. Neurosci. 19 (19): 8244-51. PMID 10493725.
Wolford JK, Bogardus C, Ossowski V, Prochazka M (2000). "Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians.". Gene 241 (1): 143-8. PMID 10607908.
Zhang Y, Redina O, Altshuller YM, et al. (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them.". J. Biol. Chem. 275 (45): 35224-32. doi:10.1074/jbc.M003329200. PMID 10926929.
Formstecher E, Ramos JW, Fauquet M, et al. (2001). "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.". Dev. Cell 1 (2): 239-50. PMID 11702783.
Condorelli G, Trencia A, Vigliotta G, et al. (2002). "Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function.". J. Biol. Chem. 277 (13): 11013-8. doi:10.1074/jbc.M110934200. PMID 11790785.
Xiao C, Yang BF, Asadi N, et al. (2002). "Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells.". J. Biol. Chem. 277 (28): 25020-5. doi:10.1074/jbc.M202946200. PMID 11976344.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Vaidyanathan H, Ramos JW (2003). "RSK2 activity is regulated by its interaction with PEA-15.". J. Biol. Chem. 278 (34): 32367-72. doi:10.1074/jbc.M303988200. PMID 12796492.
Trencia A, Perfetti A, Cassese A, et al. (2003). "Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.". Mol. Cell. Biol. 23 (13): 4511-21. PMID 12808093.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Trencia A, Fiory F, Maitan MA, et al. (2004). "Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.". J. Biol. Chem. 279 (45): 46566-72. doi:10.1074/jbc.M406317200. PMID 15328349.
Gaumont-Leclerc MF, Mukhopadhyay UK, Goumard S, Ferbeyre G (2004). "PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence.". J. Biol. Chem. 279 (45): 46802-9. doi:10.1074/jbc.M403893200. PMID 15331596.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Renganathan H, Vaidyanathan H, Knapinska A, Ramos JW (2006). "Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD.". Biochem. J. 390 (Pt 3): 729-35. doi:10.1042/BJ20050378. PMID 15916534.