PDLIM1

From Wikipedia, the free encyclopedia

PDZ and LIM domain 1 (elfin)

PDB rendering based on 1x62.

Available structures: 1x62, 2pkt

Identifiers

Symbol(s)

PDLIM1; CLIM1; CLP-36; CLP36; ELFIN; hCLIM1

External IDs

OMIM: 605900 MGI: 1860611 HomoloGene: 9643

Gene ontology
Molecular Function:	• transcription coactivator activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• transcription factor complex • cytoskeleton
Biological Process:	• response to oxidative stress • regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020992 (mRNA)
NP_066272 (protein)

XM_994083 (mRNA)
XP_999177 (protein)

Location

Chr 10: 96.99 - 97.04 Mb

Chr 19: 40.27 - 40.32 Mb

Pubmed search

[1]

[2]

PDZ and LIM domain 1 (elfin), also known as PDLIM1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDLIM1 PDZ and LIM domain 1 (elfin).

[edit] Further reading

Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B (1996). "Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL.". Gene 165 (2): 267-71. PMID 8522188.
Kotaka M, Ngai SM, Garcia-Barcelo M, et al. (1999). "Characterization of the human 36-kDa carboxyl terminal LIM domain protein (hCLIM1).". J. Cell. Biochem. 72 (2): 279-85. PMID 10022510.
Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4.". J. Biol. Chem. 275 (15): 11100-5. PMID 10753915.
Kotaka M, Kostin S, Ngai S, et al. (2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2.". J. Cell. Biochem. 78 (4): 558-65. PMID 10861853.
Bauer K, Kratzer M, Otte M, et al. (2001). "Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells.". Blood 96 (13): 4236-45. PMID 11110697.
Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99-103. doi:10.1038/416099a. PMID 11882901.
Vallenius T, Mäkelä TP (2003). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.". J. Cell. Sci. 115 (Pt 10): 2067-73. PMID 11973348.
Kioussi C, Briata P, Baek SH, et al. (2003). "Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.". Cell 111 (5): 673-85. PMID 12464179.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Miehe U, Kadyrov M, Neumaier-Wagner P, et al. (2007). "Expression of the actin stress fiber-associated protein CLP36 in the human placenta.". Histochem. Cell Biol. 126 (4): 465-71. doi:10.1007/s00418-006-0182-5. PMID 16609848.