PDGFRA

From Wikipedia, the free encyclopedia

Platelet-derived growth factor receptor, alpha polypeptide

Identifiers

PDGFRA; CD140A; MGC74795; PDGFR2; Rhe-PDGFRA

External IDs

OMIM: 173490 MGI: 97530 HomoloGene: 31361

Gene ontology
Molecular Function:	• nucleotide binding • receptor activity • platelet-derived growth factor alpha-receptor activity • vascular endothelial growth factor receptor activity • ATP binding • transferase activity • platelet-derived growth factor binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein amino acid phosphorylation • cell surface receptor linked signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • cell proliferation • organ morphogenesis • extracellular matrix organization and biogenesis • lung development • male genitalia development • odontogenesis (sensu Vertebrata)

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006206 (mRNA)
NP_006197 (protein)

NM_011058 (mRNA)
NP_035188 (protein)

Location

Chr 4: 54.79 - 54.86 Mb

Chr 5: 75.43 - 75.48 Mb

Pubmed search

[1]

[2]

Platelet-derived growth factor receptor, alpha polypeptide, also known as PDGFRA, is a human gene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.^[1]

[edit] See also

Platelet-derived growth factor receptor

[edit] References

^ Entrez Gene: PDGFRA platelet-derived growth factor receptor, alpha polypeptide.

[edit] Further reading

Hart CE, Bowen-Pope DF (1990). "Platelet-derived growth factor receptor: current views of the two-subunit model.". J. Invest. Dermatol. 94 (6 Suppl): 53S-57S. PMID 2161888.
Corless CL, Schroeder A, Griffith D, et al. (2005). "PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.". J. Clin. Oncol. 23 (23): 5357-64. doi:10.1200/JCO.2005.14.068. PMID 15928335.
Lasota J, Miettinen M (2007). "KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs).". Semin Diagn Pathol 23 (2): 91-102. PMID 17193822.