PDGFC

From Wikipedia, the free encyclopedia

Platelet derived growth factor C

Identifiers

External IDs

OMIM: 608452 MGI: 1859631 HomoloGene: 9423

Gene ontology
Molecular Function:	• growth factor activity
Cellular Component:	• extracellular region • membrane
Biological Process:	• regulation of progression through cell cycle • central nervous system development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016205 (mRNA)
NP_057289 (protein)

XM_982401 (mRNA)
XP_987495 (protein)

Location

Chr 4: 157.9 - 158.11 Mb

Chr 3: 81.12 - 81.3 Mb

Pubmed search

[1]

[2]

Platelet derived growth factor C, also known as PDGFC, is a human gene.^[1]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDGFC platelet derived growth factor C.

[edit] Further reading

Li X, Pontén A, Aase K, et al. (2000). "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.". Nat. Cell Biol. 2 (5): 302–9. doi:10.1038/35010579. PMID 10806482.
Hamada T, Ui-Tei K, Miyata Y (2000). "A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family.". FEBS Lett. 475 (2): 97–102. PMID 10858496.
Tsai YJ, Lee RK, Lin SP, Chen YH (2000). "Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract.". Biochim. Biophys. Acta 1492 (1): 196–202. PMID 11004490.
Gilbertson DG, Duff ME, West JW, et al. (2001). "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.". J. Biol. Chem. 276 (29): 27406–14. doi:10.1074/jbc.M101056200. PMID 11297552.
Zwerner JP, May WA (2001). "PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.". Oncogene 20 (5): 626–33. doi:10.1038/sj.onc.1204133. PMID 11313995.
Uutela M, Laurén J, Bergsten E, et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes.". Circulation 103 (18): 2242–7. PMID 11342471.
Zwerner JP, May WA (2002). "Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines.". Oncogene 21 (24): 3847–54. doi:10.1038/sj.onc.1205486. PMID 12032822.
Andrae J, Molander C, Smits A, et al. (2002). "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells.". Biochem. Biophys. Res. Commun. 296 (3): 604–11. PMID 12176024.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Reigstad LJ, Sande HM, Fluge Ø, et al. (2003). "Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure.". J. Biol. Chem. 278 (19): 17114–20. doi:10.1074/jbc.M301728200. PMID 12598536.
Eitner F, Ostendorf T, Kretzler M, et al. (2003). "PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases.". J. Am. Soc. Nephrol. 14 (5): 1145–53. PMID 12707385.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Fang L, Yan Y, Komuves LG, et al. (2004). "PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.". Arterioscler. Thromb. Vasc. Biol. 24 (4): 787–92. PMID 15061151.
Jinnin M, Ihn H, Mimura Y, et al. (2005). "Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts.". J. Cell. Physiol. 202 (2): 510–7. doi:10.1002/jcp.20154. PMID 15389578.
Campbell JS, Hughes SD, Gilbertson DG, et al. (2005). "Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma.". Proc. Natl. Acad. Sci. U.S.A. 102 (9): 3389–94. doi:10.1073/pnas.0409722102. PMID 15728360.
Fredriksson L, Ehnman M, Fieber C, Eriksson U (2005). "Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator.". J. Biol. Chem. 280 (29): 26856–62. doi:10.1074/jbc.M503388200. PMID 15911618.
Reigstad LJ, Martinez A, Varhaug JE, Lillehaug JR (2006). "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines.". Exp. Cell Res. 312 (6): 782–95. doi:10.1016/j.yexcr.2005.11.035. PMID 16443219.