PDF (gene)

From Wikipedia, the free encyclopedia

Peptide deformylase (mitochondrial)

Identifiers

External IDs

Gene ontology
Molecular Function:	• iron ion binding • hydrolase activity • peptide deformylase activity • metal ion binding
Cellular Component:	• mitochondrion
Biological Process:	• translation • positive regulation of cell proliferation • peptidyl-methionine modification • N-terminal protein amino acid modification

Orthologs

Human

Mouse

Entrez

64146

n/a

Refseq

NM_022341 (mRNA)
NP_071736 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Peptide deformylase (mitochondrial), also known as PDF, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDF peptide deformylase (mitochondrial).

[edit] Further reading

Lee MD, She Y, Soskis MJ, et al. (2004). "Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics.". J. Clin. Invest. 114 (8): 1107-16. doi:10.1172/JCI22269. PMID 15489958.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lee MD, Antczak C, Li Y, et al. (2004). "A new human peptide deformylase inhibitable by actinonin.". Biochem. Biophys. Res. Commun. 312 (2): 309-15. PMID 14637138.
Serero A, Giglione C, Sardini A, et al. (2004). "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.". J. Biol. Chem. 278 (52): 52953-63. doi:10.1074/jbc.M309770200. PMID 14532271.
Nguyen KT, Hu X, Colton C, et al. (2003). "Characterization of a human peptide deformylase: implications for antibacterial drug design.". Biochemistry 42 (33): 9952-8. doi:10.1021/bi0346446. PMID 12924944.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443-9. PMID 12417987.
Giglione C, Serero A, Pierre M, et al. (2000). "Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms.". EMBO J. 19 (21): 5916-29. doi:10.1093/emboj/19.21.5916. PMID 11060042.