PDE8B

From Wikipedia, the free encyclopedia

Phosphodiesterase 8B

Identifiers

PDE8B; FLJ11212

External IDs

OMIM: 603390 MGI: 2443999 HomoloGene: 2758

Gene ontology
Molecular Function:	• two-component response regulator activity • magnesium ion binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • hydrolase activity • manganese ion binding
Cellular Component:	• cellular_component
Biological Process:	• two-component signal transduction system (phosphorelay) • regulation of transcription, DNA-dependent • cyclic nucleotide metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001029851 (mRNA)
NP_001025022 (protein)

NM_172263 (mRNA)
NP_758467 (protein)

Location

Chr 5: 76.54 - 76.76 Mb

Chr 13: 96.13 - 96.32 Mb

Pubmed search

[1]

[2]

Phosphodiesterase 8B, also known as PDE8B, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDE8B phosphodiesterase 8B.

[edit] Further reading

Hayashi M, Matsushima K, Ohashi H, et al. (1998). "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase.". Biochem. Biophys. Res. Commun. 250 (3): 751–6. doi:10.1006/bbrc.1998.9379. PMID 9784418.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Persani L, Borgato S, Lania A, et al. (2001). "Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations.". J. Clin. Endocrinol. Metab. 86 (8): 3795–800. PMID 11502813.
Hayashi M, Shimada Y, Nishimura Y, et al. (2002). "Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene.". Biochem. Biophys. Res. Commun. 297 (5): 1253–8. PMID 12372422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.". Cell. Signal. 15 (6): 565–74. PMID 12681444.
Pérez-Torres S, Cortés R, Tolnay M, et al. (2003). "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization.". Exp. Neurol. 182 (2): 322–34. PMID 12895443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.