PDE7A

From Wikipedia, the free encyclopedia

Phosphodiesterase 7A

PDB rendering based on 1zkl.

Available structures: 1zkl

Identifiers

Symbol(s)

PDE7A; HCP1; PDE7

External IDs

OMIM: 171885 MGI: 1202402 HomoloGene: 1956

Gene ontology
Molecular Function:	• catalytic activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • hydrolase activity
Cellular Component:	• cell fraction
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002603 (mRNA)
NP_002594 (protein)

NM_008802 (mRNA)
NP_032828 (protein)

Location

Chr 8: 66.79 - 66.86 Mb

Chr 3: 19.42 - 19.5 Mb

Pubmed search

[1]

[2]

Phosphodiesterase 7A, also known as PDE7A, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDE7A phosphodiesterase 7A.

[edit] Further reading

Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.". Somat. Cell Mol. Genet. 20 (2): 75–86. PMID 8009369.
Michaeli T, Bloom TJ, Martins T, et al. (1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.". J. Biol. Chem. 268 (17): 12925–32. PMID 8389765.
Han P, Zhu X, Michaeli T (1997). "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.". J. Biol. Chem. 272 (26): 16152–7. PMID 9195912.
Han P, Fletcher CF, Copeland NG, et al. (1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13.". Genomics 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044.
Miró X, Casacuberta JM, Gutiérrez-López MD, et al. (2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1).". Biochem. Biophys. Res. Commun. 274 (2): 415–21. doi:10.1006/bbrc.2000.3146. PMID 10913353.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Glavas NA, Ostenson C, Schaefer JB, et al. (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. doi:10.1073/pnas.101131098. PMID 11371644.
Lee R, Wolda S, Moon E, et al. (2002). "PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.". Cell. Signal. 14 (3): 277–84. PMID 11812656.
Nakata A, Ogawa K, Sasaki T, et al. (2002). "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors.". Clin. Exp. Immunol. 128 (3): 460–6. PMID 12067300.
Smith SJ, Brookes-Fazakerley S, Donnelly LE, et al. (2003). "Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (2): L279–89. doi:10.1152/ajplung.00170.2002. PMID 12388353.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Torras-Llort M, Azorín F (2003). "Functional characterization of the human phosphodiesterase 7A1 promoter.". Biochem. J. 373 (Pt 3): 835–43. doi:10.1042/BJ20021829. PMID 12737631.
Wang H, Liu Y, Chen Y, et al. (2005). "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.". J. Biol. Chem. 280 (35): 30949–55. doi:10.1074/jbc.M504398200. PMID 15994308.