PDE6G

From Wikipedia, the free encyclopedia

Phosphodiesterase 6G, cGMP-specific, rod, gamma

PDB rendering based on 1fqj.

Available structures: 1fqj

Identifiers

Symbol(s)

PDE6G; DKFZp686C0587; MGC125749; PDEG

External IDs

OMIM: 180073 MGI: 97526 HomoloGene: 1955

Gene ontology
Molecular Function:	• 3',5'-cyclic-nucleotide phosphodiesterase activity • enzyme inhibitor activity • protein binding • hydrolase activity • cGMP binding
Biological Process:	• activation of MAPK activity • visual perception • positive regulation of epidermal growth factor receptor signaling pathway • positive regulation of G-protein coupled receptor protein signaling pathway • response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002602 (mRNA)
NP_002593 (protein)

XM_994440 (mRNA)
XP_999534 (protein)

Location

Chr 17: 77.23 - 77.23 Mb

Chr 11: 120.26 - 120.27 Mb

Pubmed search

[1]

[2]

Phosphodiesterase 6G, cGMP-specific, rod, gamma, also known as PDE6G, is a human gene.^[1]

[edit] References

^ Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma.

[edit] Further reading

Cotran PR, Bruns GA, Berson EL, Dryja TP (1992). "Genetic analysis of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase.". Exp. Eye Res. 53 (5): 557-64. PMID 1683837.
Piriev NI, Purishko VA, Khramtsov NV, Lipkin VM (1991). "[The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase]". Dokl. Akad. Nauk SSSR 315 (1): 229-31. PMID 1965799.
Pittler SJ, Baehr W, Wasmuth JJ, et al. (1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene.". Genomics 6 (2): 272-83. PMID 2155175.
Tuteja N, Danciger M, Klisak I, et al. (1990). "Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina.". Gene 88 (2): 227-32. PMID 2161380.
Piriev NI, Khramtsov NV, Lipkin VM (1995). "Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells.". Gene 151 (1-2): 297-301. PMID 7828894.
Hahn LB, Berson EL, Dryja TP (1994). "Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa.". Invest. Ophthalmol. Vis. Sci. 35 (3): 1077-82. PMID 8125719.
Dollfus H, Mattei MG, Rozet JM, et al. (1993). "Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25).". Genomics 17 (2): 526-8. doi:10.1006/geno.1993.1364. PMID 8406511.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Wan KF, Sambi BS, Frame M, et al. (2001). "The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells.". J. Biol. Chem. 276 (41): 37802-8. doi:10.1074/jbc.M105087200. PMID 11502744.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.". Mol. Vis. 8: 196-204. PMID 12107411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wan KF, Sambi BS, Tate R, et al. (2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.". J. Biol. Chem. 278 (20): 18658-63. doi:10.1074/jbc.M212103200. PMID 12624098.
Morin F, Vannier B, Houdart F, et al. (2003). "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins.". Mol. Vis. 9: 449-59. PMID 14502124.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.