PDCL

From Wikipedia, the free encyclopedia

Phosducin-like

Identifiers

PDCL; DKFZp564M1863; PhLP

External IDs

OMIM: 604421 MGI: 1914716 HomoloGene: 38043

Gene ontology
Molecular Function:	• regulator of G-protein signaling activity
Cellular Component:	• cellular_component • cytoplasm
Biological Process:	• signal transduction • visual perception • response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005388 (mRNA)
NP_005379 (protein)

NM_026176 (mRNA)
NP_080452 (protein)

Location

Chr 9: 124.62 - 124.63 Mb

Chr 2: 37.17 - 37.18 Mb

Pubmed search

[1]

[2]

Phosducin-like, also known as PDCL, is a human gene.^[1]

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: PDCL phosducin-like.

[edit] Further reading

Miles MF, Barhite S, Sganga M, Elliott M (1993). "Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10831–5. PMID 8248177.
Thibault C, Feng Wang J, Charnas R, et al. (1999). "Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization.". Biochim. Biophys. Acta 1444 (3): 346–54. PMID 10095058.
Lazarov ME, Martin MM, Willardson BM, Elton TS (1999). "Human phosducin-like protein (hPhLP) messenger RNA stability is regulated by cis-acting instability elements present in the 3'-untranslated region.". Biochim. Biophys. Acta 1446 (3): 253–64. PMID 10524200.
Ruiz-Gómez A, Humrich J, Murga C, et al. (2000). "Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.". J. Biol. Chem. 275 (38): 29724–30. doi:10.1074/jbc.M001864200. PMID 10884381.
Lazarov ME, Martin MM, Willardson BM, Elton TS (2000). "Molecular cloning and characterization of the human phosducin-like protein (hPhLP) promoter.". Biochim. Biophys. Acta 1492 (2-3): 460–4. PMID 10899582.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
McLaughlin JN, Thulin CD, Hart SJ, et al. (2002). "Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7962–7. doi:10.1073/pnas.112075699. PMID 12060742.
Humrich J, Bermel C, Grubel T, et al. (2003). "Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing.". J. Biol. Chem. 278 (7): 4474–81. doi:10.1074/jbc.M206347200. PMID 12466282.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Carter MD, Southwick K, Lukov G, et al. (2005). "Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry.". J Biomol Tech 15 (4): 257–64. PMID 15585822.
Humrich J, Bermel C, Bünemann M, et al. (2005). "Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding.". J. Biol. Chem. 280 (20): 20042–50. doi:10.1074/jbc.M409233200. PMID 15745879.
Lukov GL, Hu T, McLaughlin JN, et al. (2005). "Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly.". EMBO J. 24 (11): 1965–75. doi:10.1038/sj.emboj.7600673. PMID 15889144.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Lukov GL, Baker CM, Ludtke PJ, et al. (2006). "Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex.". J. Biol. Chem. 281 (31): 22261–74. doi:10.1074/jbc.M601590200. PMID 16717095.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.