PDCD6

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Programmed cell death 6
PDB rendering based on 1hqv.
Available structures: 1hqv
Identifiers
Symbol(s) PDCD6; ALG-2; MGC111017; MGC119050; MGC9123; PEF1B
External IDs OMIM: 601057 MGI: 109283 HomoloGene: 7880
Orthologs
Human Mouse
Entrez 10016 18570
Ensembl n/a ENSMUSG00000021576
Uniprot n/a Q3UGE5
Refseq NM_013232 (mRNA)
NP_037364 (protein)		 NM_011051 (mRNA)
NP_035181 (protein)
Location n/a Chr 13: 74.77 - 74.78 Mb
Pubmed search [1] [2]

Programmed cell death 6, also known as PDCD6, is a human gene.

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.[1]

[edit] References

  1. ^ Entrez Gene: PDCD6 programmed cell death 6.

[edit] Further reading

  • Krebs J, Klemenz R (2001). "The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis.". Biochim. Biophys. Acta 1498 (2-3): 153–61. PMID 11108958. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Vito P, Lacanà E, D'Adamio L (1996). "Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3.". Science 271 (5248): 521–5. PMID 8560270. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Vito P, Pellegrini L, Guiet C, D'Adamio L (1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction.". J. Biol. Chem. 274 (3): 1533–40. PMID 9880530. 
  • Tarabykina S, Møller AL, Durussel I, et al. (2000). "Two forms of the apoptosis-linked protein ALG-2 with different Ca(2+) affinities and target recognition.". J. Biol. Chem. 275 (14): 10514–8. PMID 10744743. 
  • Chen B, Borinstein SC, Gillis J, et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes.". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458. 
  • Kitaura Y, Matsumoto S, Satoh H, et al. (2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner.". J. Biol. Chem. 276 (17): 14053–8. doi:10.1074/jbc.M008649200. PMID 11278427. 
  • Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653. 
  • Jung YS, Kim KS, Kim KD, et al. (2001). "Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells.". Biochem. Biophys. Res. Commun. 288 (2): 420–6. doi:10.1006/bbrc.2001.5769. PMID 11606059. 
  • Kitaura Y, Satoh H, Takahashi H, et al. (2002). "Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions.". Arch. Biochem. Biophys. 399 (1): 12–8. doi:10.1006/abbi.2001.2736. PMID 11883899. 
  • Satoh H, Shibata H, Nakano Y, et al. (2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner.". Biochem. Biophys. Res. Commun. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. PMID 11883939. 
  • Chatellard-Causse C, Blot B, Cristina N, et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747. 
  • Hwang IS, Jung YS, Kim E (2002). "Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation.". FEBS Lett. 529 (2-3): 183–7. PMID 12372597. 
  • Satoh H, Nakano Y, Shibata H, Maki M (2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner.". Biochim. Biophys. Acta 1600 (1-2): 61–7. PMID 12445460. 
  • Krebs J, Saremaslani P, Caduff R (2002). "ALG-2: a Ca2+ -binding modulator protein involved in cell proliferation and in cell death.". Biochim. Biophys. Acta 1600 (1-2): 68–73. PMID 12445461. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145. 
  • Hansen C, Tarabykina S, la Cour JM, et al. (2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro.". FEBS Lett. 545 (2-3): 151–4. PMID 12804766. 
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