PDCD10
From Wikipedia, the free encyclopedia
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Programmed cell death 10
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| Identifiers | ||||||||
| Symbol(s) | PDCD10; CCM3; MGC1212; MGC24477; TFAR15 | |||||||
| External IDs | OMIM: 609118 MGI: 1928396 HomoloGene: 10505 | |||||||
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| RNA expression pattern | ||||||||
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| Orthologs | ||||||||
| Human | Mouse | |||||||
| Entrez | 11235 | 56426 | ||||||
| Ensembl | ENSG00000114209 | ENSMUSG00000027835 | ||||||
| Uniprot | Q9BUL8 | Q3TVB4 | ||||||
| Refseq | NM_007217 (mRNA) NP_009148 (protein) |
NM_019745 (mRNA) NP_062719 (protein) |
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| Location | Chr 3: 168.88 - 168.94 Mb | Chr 3: 75.6 - 75.64 Mb | ||||||
| Pubmed search | [1] | [2] | ||||||
Programmed cell death 10, also known as PDCD10, is a human gene.[1]
This gene encodes a protein, originally identified in a premyeloid cell line, with similarity to proteins that participate in apoptosis. Three alternative transcripts encoding the same protein, differing only in their 5' UTRs, have been identified for this gene.[1]
[edit] References
[edit] Further reading
- Craig HD, Günel M, Cepeda O, et al. (1998). "Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27.". Hum. Mol. Genet. 7 (12): 1851-8. PMID 9811928.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Bergametti F, Denier C, Labauge P, et al. (2005). "Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations.". Am. J. Hum. Genet. 76 (1): 42-51. doi:. PMID 15543491.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:. PMID 16189514.
- Guclu B, Ozturk AK, Pricola KL, et al. (2006). "Cerebral venous malformations have distinct genetic origin from cerebral cavernous malformations.". Stroke 36 (11): 2479-80. doi:. PMID 16239636.
- Guclu B, Ozturk AK, Pricola KL, et al. (2006). "Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3.". Neurosurgery 57 (5): 1008-13. PMID 16284570.
- Liquori CL, Berg MJ, Squitieri F, et al. (2006). "Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus.". Hum. Mutat. 27 (1): 118. doi:. PMID 16329096.
- Verlaan DJ, Roussel J, Laurent SB, et al. (2006). "CCM3 mutations are uncommon in cerebral cavernous malformations.". Neurology 65 (12): 1982-3. doi:. PMID 16380626.
- Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.". Genomics 88 (3): 333-46. doi:. PMID 16730941.
- Labauge P, Krivosic V, Denier C, et al. (2006). "Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study.". Arch. Ophthalmol. 124 (6): 885-6. doi:. PMID 16769843.
- Chen PY, Chang WS, Chou RH, et al. (2007). "Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner.". BMC Mol. Biol. 8: 2. doi:. PMID 17212813.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:. PMID 17353931.
- Ma X, Zhao H, Shan J, et al. (2007). "PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.". Mol. Biol. Cell 18 (6): 1965-78. doi:. PMID 17360971.
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