PCOLCE

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Procollagen C-endopeptidase enhancer
PDB rendering based on 1uap.
Available structures: 1uap
Identifiers
Symbol(s) PCOLCE; PCPE
External IDs OMIM: 600270 MGI: 105099 HomoloGene: 1946
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5118 18542
Ensembl ENSG00000106333 ENSMUSG00000029718
Uniprot Q15113 Q3TX39
Refseq NM_002593 (mRNA)
NP_002584 (protein)		 NM_008788 (mRNA)
NP_032814 (protein)
Location Chr 7: 100.04 - 100.04 Mb Chr 5: 137.83 - 137.84 Mb
Pubmed search [1] [2]

Procollagen C-endopeptidase enhancer, also known as PCOLCE, is a human gene.[1]

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.[1]

[edit] References

  1. ^ a b Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer.

[edit] Further reading

  • Takahara K, Kessler E, Biniaminov L, et al. (1994). "Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE).". J. Biol. Chem. 269 (42): 26280-5. PMID 7523404. 
  • Takahara K, Osborne L, Elliott RW, et al. (1997). "Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein.". Genomics 31 (2): 253-6. doi:10.1006/geno.1996.0043. PMID 8824813. 
  • Glöckner G, Scherer S, Schattevoy R, et al. (1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.". Genome Res. 8 (10): 1060-73. PMID 9799793. 
  • Scott IC, Clark TG, Takahara K, et al. (1999). "Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein.". Genomics 55 (2): 229-34. doi:10.1006/geno.1998.5663. PMID 9933570. 
  • Mott JD, Thomas CL, Rosenbach MT, et al. (2000). "Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.". J. Biol. Chem. 275 (2): 1384-90. PMID 10625689. 
  • Ricard-Blum S, Bernocco S, Font B, et al. (2002). "Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1.". J. Biol. Chem. 277 (37): 33864-9. doi:10.1074/jbc.M205018200. PMID 12105202. 
  • Ligon AH, Scott IC, Takahara K, et al. (2002). "PCOLCE deletion and expression analyses in uterine leiomyomata.". Cancer Genet. Cytogenet. 137 (2): 133-7. PMID 12393284. 
  • Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.". J. Biol. Chem. 277 (51): 49820-30. doi:10.1074/jbc.M209891200. PMID 12393877. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bernocco S, Steiglitz BM, Svergun DI, et al. (2003). "Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein.". J. Biol. Chem. 278 (9): 7199-205. doi:10.1074/jbc.M210857200. PMID 12486138. 
  • Liepinsh E, Banyai L, Pintacuda G, et al. (2003). "NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding.". J. Biol. Chem. 278 (28): 25982-9. doi:10.1074/jbc.M302734200. PMID 12670942. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Petropoulou V, Garrigue-Antar L, Kadler KE (2005). "Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).". J. Biol. Chem. 280 (24): 22616-23. doi:10.1074/jbc.M413468200. PMID 15817489. 
  • Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006). "Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.". J. Biol. Chem. 281 (16): 10786-98. doi:10.1074/jbc.M511111200. PMID 16507574. 
  • Blanc G, Font B, Eichenberger D, et al. (2007). "Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity.". J. Biol. Chem. 282 (23): 16924-33. doi:10.1074/jbc.M701610200. PMID 17446170. 
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