PCDH1

From Wikipedia, the free encyclopedia

Protocadherin 1

Identifiers

PCDH1; MGC45991; PC42; PCDH42

External IDs

OMIM: 603626 MGI: 104692 HomoloGene: 12613

Gene ontology
Molecular Function:	• DNA binding • transcription elongation regulator activity • calcium ion binding • protein binding
Cellular Component:	• plasma membrane • integral to plasma membrane • intercellular junction • membrane
Biological Process:	• regulation of transcription, DNA-dependent • cell adhesion • homophilic cell adhesion • cell-cell signaling • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002587 (mRNA)
NP_002578 (protein)

NM_029357 (mRNA)
NP_083633 (protein)

Location

Chr 5: 141.21 - 141.24 Mb

Chr 18: 38.32 - 38.34 Mb

Pubmed search

[1]

[2]

Protocadherin 1, also known as PCDH1, is a human gene.^[1]

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCDH1 protocadherin 1.

[edit] Further reading

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169-80. PMID 10817752.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551-72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Sano K, Tanihara H, Heimark RL, et al. (1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system.". EMBO J. 12 (6): 2249-56. PMID 8508762.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Del Mastro RG, Wang L, Simmons AD, et al. (1997). "Human chromosome-specific cDNA libraries: new tools for gene identification and genome annotation.". Genome Res. 5 (2): 185-94. PMID 9132272.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124-9. doi:10.1073/pnas.060027397. PMID 10716726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.