PCDH12

From Wikipedia, the free encyclopedia

Protocadherin 12

Identifiers

PCDH12; VE-cadherin-2; VECAD2

External IDs

OMIM: 605622 MGI: 1855700 HomoloGene: 9574

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• cytoskeleton • plasma membrane • integral to plasma membrane • intercellular junction
Biological Process:	• cell adhesion • homophilic cell adhesion • neuron recognition • calcium-dependent cell-cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016580 (mRNA)
NP_057664 (protein)

NM_017378 (mRNA)
NP_059074 (protein)

Location

Chr 5: 141.3 - 141.32 Mb

Chr 18: 38.39 - 38.41 Mb

Pubmed search

[1]

[2]

Protocadherin 12, also known as PCDH12, is a human gene.^[1]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCDH12 protocadherin 12.

[edit] Further reading

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169–80. PMID 10817752.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Telo' P, Breviario F, Huber P, et al. (1998). "Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells.". J. Biol. Chem. 273 (28): 17565–72. PMID 9651350.
Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes.". Cell 97 (6): 779–90. PMID 10380929.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMID 10716726.
Ludwig D, Lorenz J, Dejana E, et al. (2001). "cDNA cloning, chromosomal mapping, and expression analysis of human VE-Cadherin-2.". Mamm. Genome 11 (11): 1030–3. PMID 11063261.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.