PB28
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| PD28 | |
|---|---|
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| IUPAC name | 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetra-
hydronaphthalen-1-yl)propyl]piperazine |
| Other names | PD28 |
| Identifiers | |
| CAS number | |
| SMILES | COc1c(CCCC2CCCN3CCN(C4CCCCC4)CC3)c2ccc1 |
| Properties | |
| Molecular formula | C24H38N2O |
| Molar mass | 370.57 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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PB28[1] is an agonist of the sigma-2 receptor.[2][3]
It is derived from cyclohexylpiperazine.
[edit] References
- ^ Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L (1996). "New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives". J. Med. Chem. 39 (1): 176–82. doi:. PMID 8568804.
- ^ Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA (2006). "The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells". Cell Calcium 40 (1): 23–8. doi:. PMID 16687172.
- ^ Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A (2006). "Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer". Mol. Cancer Ther. 5 (7): 1807–16. doi:. PMID 16891467.
[edit] External links
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