Paxillin

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Paxillin
Identifiers
Symbol(s) PXN; FLJ16691
External IDs OMIM: 602505 MGI: 108295 HomoloGene: 37697
Orthologs
Human Mouse
Entrez 5829 19303
Ensembl n/a ENSMUSG00000029528
Uniprot n/a O88294
Refseq NM_002859 (mRNA)
NP_002850 (protein)		 NM_011223 (mRNA)
NP_035353 (protein)
Location n/a Chr 5: 115.77 - 115.82 Mb
Pubmed search [1] [2]

Paxillin is a signal transduction adaptor protein and should be not be confused with the neurotoxin paxilline.

[edit] Further reading

  • Turner CE (1998). "Paxillin.". Int. J. Biochem. Cell Biol. 30 (9): 955–9. PMID 9785458. 
  • Panetti TS (2002). "Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration.". Front. Biosci. 7: d143–50. PMID 11779709. 
  • Rose DM, Han J, Ginsberg MH (2003). "Alpha4 integrins and the immune response.". Immunol. Rev. 186: 118–24. PMID 12234367. 
  • Salgia R, Uemura N, Okuda K, et al. (1996). "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells.". J. Biol. Chem. 270 (49): 29145–50. PMID 7493940. 
  • Turner CE, Miller JT (1994). "Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region.". J. Cell. Sci. 107 ( Pt 6): 1583–91. PMID 7525621. 
  • Bergman M, Joukov V, Virtanen I, Alitalo K (1995). "Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading.". Mol. Cell. Biol. 15 (2): 711–22. PMID 7529872. 
  • Salgia R, Li JL, Lo SH, et al. (1995). "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.". J. Biol. Chem. 270 (10): 5039–47. PMID 7534286. 
  • Schaller MD, Otey CA, Hildebrand JD, Parsons JT (1995). "Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.". J. Cell Biol. 130 (5): 1181–7. PMID 7657702. 
  • Yoshida M, Westlin WF, Wang N, et al. (1996). "Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.". J. Cell Biol. 133 (2): 445–55. PMID 8609175. 
  • Salgia R, Sattler M, Pisick E, et al. (1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.". Exp. Hematol. 24 (2): 310–3. PMID 8641358. 
  • Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.". J. Biol. Chem. 271 (41): 25198–203. PMID 8810278. 
  • Brown MC, Perrotta JA, Turner CE (1997). "Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.". J. Cell Biol. 135 (4): 1109–23. PMID 8922390. 
  • Retta SF, Barry ST, Critchley DR, et al. (1997). "Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity.". Exp. Cell Res. 229 (2): 307–17. doi:10.1006/excr.1996.0376. PMID 8986614. 
  • Mazaki Y, Hashimoto S, Sabe H (1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins.". J. Biol. Chem. 272 (11): 7437–44. PMID 9054445. 
  • Hiregowdara D, Avraham H, Fu Y, et al. (1997). "Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin.". J. Biol. Chem. 272 (16): 10804–10. PMID 9099734. 
  • Ostergaard HL, Lou O, Arendt CW, Berg NN (1998). "Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells.". J. Biol. Chem. 273 (10): 5692–6. PMID 9488700. 
  • Fernandez R, Suchard SJ (1998). "Syk activation is required for spreading and H2O2 release in adherent human neutrophils.". J. Immunol. 160 (10): 5154–62. PMID 9590268. 
  • Lewis JM, Schwartz MA (1998). "Integrins regulate the association and phosphorylation of paxillin by c-Abl.". J. Biol. Chem. 273 (23): 14225–30. PMID 9603926. 
  • Ganju RK, Munshi N, Nair BC, et al. (1998). "Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.". J. Virol. 72 (7): 6131–7. PMID 9621077. 

[edit] External links

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