PARK7

From Wikipedia, the free encyclopedia

Parkinson disease (autosomal recessive, early onset) 7

PDB rendering based on 1j42.

Available structures: 1j42, 1p5f, 1pdv, 1pdw, 1pe0, 1ps4, 1q2u, 1soa, 1ucf, 2or3

Identifiers

Symbol(s)

PARK7; DJ-1; DJ1; FLJ27376

External IDs

OMIM: 602533 MGI: 2135637 HomoloGene: 38295

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein folding • Ras protein signal transduction • adult locomotory behavior • response to hydrogen peroxide • dopamine uptake

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007262 (mRNA)
NP_009193 (protein)

NM_020569 (mRNA)
NP_065594 (protein)

Location

Chr 1: 7.94 - 7.97 Mb

Chr 4: 149.74 - 149.75 Mb

Pubmed search

[1]

[2]

Parkinson disease (autosomal recessive, early onset) 7, also known as PARK7, is a human gene. It is also known as DJ-1.

[edit] See also

Parkinson's disease

[edit] Further reading

Cookson MR (2003). "Pathways to Parkinsonism.". Neuron 37 (1): 7–10. PMID 12526767.
Bonifati V, Oostra BA, Heutink P (2004). "Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease.". J. Mol. Med. 82 (3): 163–74. doi:10.1007/s00109-003-0512-1. PMID 14712351.
Le W, Appel SH (2004). "Mutant genes responsible for Parkinson's disease.". Current opinion in pharmacology 4 (1): 79–84. doi:10.1016/j.coph.2003.09.005. PMID 15018843.
Abou-Sleiman PM, Healy DG, Wood NW (2005). "Causes of Parkinson's disease: genetics of DJ-1.". Cell Tissue Res. 318 (1): 185–8. doi:10.1007/s00441-004-0922-6. PMID 15503154.
Pankratz N, Foroud T (2005). "Genetics of Parkinson disease.". NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 1 (2): 235–42. PMID 15717024.
Heutink P (2006). "PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease.". J. Neural Transm. Suppl. (70): 215–9. PMID 17017532.
Lev N, Roncevic D, Roncevich D, et al. (2007). "Role of DJ-1 in Parkinson's disease.". J. Mol. Neurosci. 29 (3): 215–25. PMID 17085780.
Nagakubo D, Taira T, Kitaura H, et al. (1997). "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.". Biochem. Biophys. Res. Commun. 231 (2): 509–13. doi:10.1006/bbrc.1997.6132. PMID 9070310.
Taira T, Takahashi K, Kitagawa R, et al. (2001). "Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.". Gene 263 (1-2): 285–92. PMID 11223268.
van Duijn CM, Dekker MC, Bonifati V, et al. (2001). "Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.". Am. J. Hum. Genet. 69 (3): 629–34. PMID 11462174.
Takahashi K, Taira T, Niki T, et al. (2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.". J. Biol. Chem. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.
Bonifati V, Rizzu P, van Baren MJ, et al. (2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.". Science 299 (5604): 256–9. doi:10.1126/science.1077209. PMID 12446870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bonifati V, Dekker MC, Vanacore N, et al. (2003). "Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7.". Neurol. Sci. 23 Suppl 2: S59–60. doi:10.1007/s100720200069. PMID 12548343.
Niki T, Takahashi-Niki K, Taira T, et al. (2004). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.". Mol. Cancer Res. 1 (4): 247–61. PMID 12612053.
Tao X, Tong L (2003). "Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease.". J. Biol. Chem. 278 (33): 31372–9. doi:10.1074/jbc.M304221200. PMID 12761214.
Honbou K, Suzuki NN, Horiuchi M, et al. (2003). "The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.". J. Biol. Chem. 278 (33): 31380–4. doi:10.1074/jbc.M305878200. PMID 12796482.
Dekker M, Bonifati V, van Swieten J, et al. (2004). "Clinical features and neuroimaging of PARK7-linked parkinsonism.". Mov. Disord. 18 (7): 751–7. doi:10.1002/mds.10422. PMID 12815653.
Miller DW, Ahmad R, Hague S, et al. (2003). "L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.". J. Biol. Chem. 278 (38): 36588–95. doi:10.1074/jbc.M304272200. PMID 12851414.