PARG

From Wikipedia, the free encyclopedia

Poly (ADP-ribose) glycohydrolase

Identifiers

PARG; PARG99

External IDs

OMIM: 603501 MGI: 1347094 HomoloGene: 50532

Gene ontology
Molecular Function:	• poly(ADP-ribose) glycohydrolase activity • hydrolase activity
Cellular Component:	• nucleus • cytoplasm • cytosol
Biological Process:	• response to DNA damage stimulus • detection of bacterium

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_937616 (mRNA)
XP_942709 (protein)

NM_011960 (mRNA)
NP_036090 (protein)

Location

n/a

Chr 14: 31.03 - 31.13 Mb

Pubmed search

[1]

[2]

Poly (ADP-ribose) glycohydrolase, also known as PARG, is a human gene.^[1]

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.^[1]

[edit] References

^ ^a ^b Entrez Gene: PARG poly (ADP-ribose) glycohydrolase.

[edit] Further reading

Bonicalzi ME, Haince JF, Droit A, Poirier GG (2005). "Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when?". Cell. Mol. Life Sci. 62 (7-8): 739–50. doi:10.1007/s00018-004-4505-1. PMID 15868399.
Uchida K, Suzuki H, Maruta H, et al. (1993). "Preferential degradation of protein-bound (ADP-ribose)n by nuclear poly(ADP-ribose) glycohydrolase from human placenta.". J. Biol. Chem. 268 (5): 3194–200. PMID 8428996.
Lin W, Amé JC, Aboul-Ela N, et al. (1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase.". J. Biol. Chem. 272 (18): 11895–901. PMID 9115250.
Winstall E, Affar EB, Shah R, et al. (1999). "Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein.". Exp. Cell Res. 246 (2): 395–8. doi:10.1006/excr.1998.4321. PMID 9925755.
Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization.". Cytogenet. Cell Genet. 85 (3-4): 269–70. PMID 10449915.
Affar EB, Germain M, Winstall E, et al. (2001). "Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis.". J. Biol. Chem. 276 (4): 2935–42. doi:10.1074/jbc.M007269200. PMID 11053413.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ohashi S, Kanai M, Hanai S, et al. (2003). "Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells.". Biochem. Biophys. Res. Commun. 307 (4): 915–21. PMID 12878198.
Meyer RG, Meyer-Ficca ML, Jacobson EL, Jacobson MK (2003). "Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23).". Gene 314: 181–90. PMID 14527731.
Golovanov AP, Barillà D, Golovanova M, et al. (2004). "ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure.". Mol. Microbiol. 50 (4): 1141–53. PMID 14622405.
Keil C, Petermann E, Oei SL (2004). "Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts.". Arch. Biochem. Biophys. 425 (1): 115–21. doi:10.1016/j.abb.2004.02.024. PMID 15081900.
Meyer-Ficca ML, Meyer RG, Coyle DL, et al. (2004). "Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments.". Exp. Cell Res. 297 (2): 521–32. doi:10.1016/j.yexcr.2004.03.050. PMID 15212953.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Putt KS, Hergenrother PJ (2005). "A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation.". Anal. Biochem. 333 (2): 256–64. doi:10.1016/j.ab.2004.04.032. PMID 15450800.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gagné JP, Bonicalzi ME, Gagné P, et al. (2006). "Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles.". Biochem. J. 392 (Pt 3): 499–509. doi:10.1042/BJ20050792. PMID 16117724.
Blenn C, Althaus FR, Malanga M (2006). "Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death.". Biochem. J. 396 (3): 419–29. doi:10.1042/BJ20051696. PMID 16526943.
Keil C, Gröbe T, Oei SL (2006). "MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1.". J. Biol. Chem. 281 (45): 34394–405. doi:10.1074/jbc.M606470200. PMID 16963444.
Meyer RG, Meyer-Ficca ML, Whatcott CJ, et al. (2007). "Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity.". Exp. Cell Res. 313 (13): 2920–36. doi:10.1016/j.yexcr.2007.03.043. PMID 17509564.