Talk:Pantothenic acid
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[edit] text against use of b5 in treatment acne
I am very skeptical on this subject so I went to GNC today and bought a bottle of Pantothenic Acid 500 in attempt to cure my random Cystic Acne breakouts. I will track the improvement or lack there of and will respond back in two weeks (6/25/2008). Today is 6/11/08.
From your point of view it is not important what is in the article but who wrote it . Your basic argument is poor scientific value of Leung's research . Arguments such as "random junk" and "rediciulous journal" are not scientific also . If you want to explain that b5 not work in treatment of acne give as some proof that there is no conection between condition in which there is not enough coenzyme A and in which acne appears . Proof that b5 not give as more of coenzyme A is also valuable.
Vitamin B5 turns up on a site linked to by BoingBoing.
http://www.brilliantdreams.com/product/dream-recall.htm
Personally, I've had experience of Lucid Dreaming, and so the "product" looked interesting, but a bit more research and I'm not so sure.
So the article should read... "According to Lehman Brothers Investment Bankers, it works!" ;)
I have just started using b5 and my spots are clearing up already, and I have tried pretty much everything under the sun so it is not a placebo.
What is proof that man who wrote this , against b5 , is not from company that produce roaccutane ? (anonymous, 212.200.198.1)
I assure you that I'm not from any company, I'm a student (see my contribs, I post from the 18.0.0.0/8 block, MIT).
Either way, I'm not "anti-b5" or pro-any product. Simply, the "research" posted on the article is extremely sketchy. One random paper published in an unheard of journal is /not/ scientific and does not define the role of B5 pills.
Simply put, just search PubMed for vitamin b / pantothenic acid / acne vulgaris, and you get practically no papers that argue that B vitamins reduce acne.
There is a substantial body of literature that argues for Vitamin A reduction of acne, and there are also documented cases of high-dose B vitamins /causing/ acne: PMID 1834437 --crl620 04:49, 5 May 2006 (UTC)
[edit] Rewrite
This article needs a complete rewrite. There is little information actually pertaining to Pantothenic acid, and lots of random junk about Dr. Lit-Hung Leung's research.
[edit] Dr. Leung
The 'study' performed by Dr. Lit-Hung Leung is extremely vague, published in a rediculous journal, and used commonly to sell B5 pills. The wiki page reads like an infomercial:
"Though this study was done in 1997, news did not spread...however, by word of mouth and eventually the internet, success stories have came in by the thousands..."
Here's the Leung article: PMID 7476595
It was published in the journal "Medical Hypotheses," which is described on their site as:
"Medical Hypotheses takes a deliberately different approach to peer review. Most contemporary practice tends to discriminate against radical ideas that conflict with current theory and practice. Medical Hypotheses will publish radical ideas, so long as they are coherent and clearly expressed. Furthermore, traditional peer review can oblige authors to distort their true views to satisfy referees, and so diminish authorial responsibility and accountability. In Medical Hypotheses, the authors' responsibility for the integrity, precision and accuracy of their work is paramount. The editor sees his role as a 'chooser', not a 'changer': choosing to publish what are judged to be the best papers from those submitted."
It looks like it's a journal without any review system.
[edit] Other Issues
Overall the data on the wiki are poorly cited and shallow.
The wiki lacks clear scientific evidence and has no sources (minus the link to "Coenzyme-A Technologies", a company selling skin products).
Legitimate and well regarded sources tend to disagree with some of the suggestions on the wiki page. The Pauling Institute describes pantothenic acid as helping to heal skin wounds, whereas the wiki article says that "Some users report that cuts heal very slowly."
Some key facts about pantothenic acid are missing, such as recent research, absorption as d-Calcium pantothenate, chemical structure, and metabolism. As Dan| says below, the information about metabolism and "part of Coenzyme-A" makes no sense. To answer Dan's question, the pantothenate is a CoA precursor: KEGG CoA Pathway
This article needs to be substantially rewritten.
[edit] Older Talk
Regarding "It is also needed for proper and healthy growth of hair," is this here because certain shampoo companies say it's true or because it's actually the case? All I can find are suggestions that the use of this chemical in shampoos has no effect, eg [1] - 203.132.90.8 03:39, 4 Jun 2005 (UTC)
"Specifically, it is part of coenzyme-A (CoASH) in the metabolism and transfer of carbon chains."
[edit] B5
Using B5 as a treatment to acne really does work. I myself have had amazing results from it, and I am also aware of several other successful cases. I can't agree or disagree with the reasoning behind it, but there is little point arguing its effectiveness having seen the dramatic changes it has had.
[edit] Prescription?
From the article, under disputed uses -> acne
"few if any dermatologists prescribe high-dose pantothenic acid."
Admittedly, few dermatologists (or any doctors, for that matter) prescribe pantothenic acid, but isn't that simply because one cannot prescribe things like vitamins/mineral/herbal supplements? A deficiency in Vitamin C, for example, can produce scurvy, however doctors wouldn't be able to prescribe you Vitamin C. They would, most likely, recommend it.
Also, perhaps someone could add that while studies are scarce, a large amount anecdotal evidence seems to support pantothenic acid's positive effects on acne? —The preceding unsigned comment was added by 74.132.210.179 (talk) 03:37, 25 April 2007 (UTC).
