Pantothenase

From Wikipedia, the free encyclopedia

In enzymology, a pantothenase (EC 3.5.1.22) is an enzyme that catalyzes the chemical reaction

(R)-pantothenate + H₂O (R)-pantoate + beta-alanine

Thus, the two substrates of this enzyme are (R)-pantothenate and H₂O, whereas its two products are (R)-pantoate and beta-alanine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantothenate amidohydrolase. Other names in common use include pantothenate hydrolase, and pantothenate amidohydrolase. This enzyme participates in pantothenate and coa biosynthesis.

[edit] References

• IUBMB entry for 3.5.1.22
• BRENDA references for 3.5.1.22 (Recommended.)
• PubMed references for 3.5.1.22
• PubMed Central references for 3.5.1.22
• Google Scholar references for 3.5.1.22
• Nurmikko V, Salo E, Hakola H, Makinen K, Snell EE (1966). "The bacterial degradation of pantothenic acid. II. Pantothenate hydrolase". Biochemistry. 5: 399–402. doi:10.1021/bi00866a002. PMID 5940928. 

[edit] External links

The CAS registry number for this enzyme class is 9076-90-8.

• IUBMB entry for 3.5.1.22

• KEGG entry for 3.5.1.22

• BRENDA entry for 3.5.1.22

• NiceZyme view of 3.5.1.22

• EC2PDB: PDB structures for 3.5.1.22

• PRIAM entry for 3.5.1.22

• PUMA2 entry for 3.5.1.22

• IntEnz: Integrated Enzyme entry for 3.5.1.22

• MetaCyc entry for 3.5.1.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004593: pantothenase

• AMIGO entry for GO code 0004593: pantothenase