PANK4

From Wikipedia, the free encyclopedia

Pantothenate kinase 4

Identifiers

PANK4; DKFZp547M242; FLJ10782

External IDs

OMIM: 606162 MGI: 2387466 HomoloGene: 41235

Gene ontology
Molecular Function:	• nucleotide binding • pantothenate kinase activity • ATP binding • transferase activity
Biological Process:	• coenzyme A biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018216 (mRNA)
NP_060686 (protein)

NM_172990 (mRNA)
NP_766578 (protein)

Location

Chr 1: 2.43 - 2.45 Mb

Chr 4: 153.81 - 153.82 Mb

Pubmed search

[1]

[2]

Pantothenate kinase 4, also known as PANK4, is a human gene.^[1]

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.^[1]

[edit] References

^ ^a ^b Entrez Gene: PANK4 pantothenate kinase 4.

[edit] Further reading

Robishaw JD, Neely JR (1985). "Coenzyme A metabolism.". Am. J. Physiol. 248 (1 Pt 1): E1–9. PMID 2981478.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Zhou B, Westaway SK, Levinson B, et al. (2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.". Nat. Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Li Y, Chang Y, Zhang L, et al. (2005). "High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2).". Mol. Cell. Biochem. 277 (1-2): 117–25. doi:10.1007/s11010-005-5535-1. PMID 16132722.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.