PALLD

From Wikipedia, the free encyclopedia

Palladin, cytoskeletal associated protein

PDB rendering based on 2dm2.

Available structures: 2dm2, 2dm3

Identifiers

Symbol(s)

PALLD; CGI-151; FLJ22190; FLJ38193; FLJ39139; KIAA0992; PNCA1; SIH002

External IDs

OMIM: 608092 MGI: 1919583 HomoloGene: 75052

Gene ontology
Molecular Function:	• receptor activity • vascular endothelial growth factor receptor activity • protein binding • ATP binding • muscle alpha-actinin binding
Cellular Component:	• nucleus • actin filament
Biological Process:	• protein amino acid phosphorylation • cytoskeleton organization and biogenesis

Orthologs

Human

Mouse

Refseq

NM_016081 (mRNA)
NP_057165 (protein)

XM_204283 (mRNA)
XP_204283 (protein)

Location

Chr 4: 169.65 - 170.09 Mb

Chr 8: 64.41 - 64.79 Mb

Pubmed search

[1]

[2]

Palladin, cytoskeletal associated protein, also known as PALLD, is a human gene.^[1]

Palladin is a component of actin-containing microfilaments that control cell shape, adhesion, and contraction.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PALLD palladin, cytoskeletal associated protein.

[edit] Further reading

King CM, Olive CW, Cardona RA (1975). "Activation of carcinogenic arylhydroxamic acids by human tissues.". J. Natl. Cancer Inst. 55 (2): 285–7. PMID 1159819.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Parast MM, Otey CA (2000). "Characterization of palladin, a novel protein localized to stress fibers and cell adhesions.". J. Cell Biol. 150 (3): 643–56. PMID 10931874.
Bang ML, Mudry RE, McElhinny AS, et al. (2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.". J. Cell Biol. 153 (2): 413–27. PMID 11309420.
Mykkänen OM, Grönholm M, Rönty M, et al. (2002). "Characterization of human palladin, a microfilament-associated protein.". Mol. Biol. Cell 12 (10): 3060–73. PMID 11598191.
Eberle MA, Pfützer R, Pogue-Geile KL, et al. (2002). "A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34.". Am. J. Hum. Genet. 70 (4): 1044–8. PMID 11870593.
Moriyama K, Bonifacino JS (2003). "Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles.". Traffic 3 (9): 666–77. PMID 12191018.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee SY, Obata Y, Yoshida M, et al. (2003). "Immunomic analysis of human sarcoma.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–6. doi:10.1073/pnas.0437972100. PMID 12601173.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rönty M, Taivainen A, Moza M, et al. (2004). "Molecular analysis of the interaction between palladin and alpha-actinin.". FEBS Lett. 566 (1-3): 30–4. doi:10.1016/j.febslet.2004.04.006. PMID 15147863.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rönty M, Taivainen A, Moza M, et al. (2005). "Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton.". Exp. Cell Res. 310 (1): 88–98. doi:10.1016/j.yexcr.2005.06.026. PMID 16125169.
Shiffman D, Ellis SG, Rowland CM, et al. (2005). "Identification of four gene variants associated with myocardial infarction.". Am. J. Hum. Genet. 77 (4): 596–605. doi:10.1086/491674. PMID 16175505.
Boukhelifa M, Moza M, Johansson T, et al. (2006). "The proline-rich protein palladin is a binding partner for profilin.". FEBS J. 273 (1): 26–33. doi:10.1111/j.1742-4658.2005.05036.x. PMID 16367745.
Rönty MJ, Leivonen SK, Hinz B, et al. (2007). "Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation.". J. Invest. Dermatol. 126 (11): 2387–96. doi:10.1038/sj.jid.5700427. PMID 16794588.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.