PAIP2

From Wikipedia, the free encyclopedia

Poly(A) binding protein interacting protein 2

Identifiers

PAIP2; MGC72018

External IDs

OMIM: 605604 MGI: 1915119 HomoloGene: 22978

Gene ontology
Molecular Function:	• protein binding • translation repressor activity
Cellular Component:	• cytoplasm
Biological Process:	• regulation of translation • negative regulation of translational initiation

Orthologs

Human

Mouse

Refseq

NM_001033112 (mRNA)
NP_001028284 (protein)

NM_026420 (mRNA)
NP_080696 (protein)

Location

Chr 5: 138.71 - 138.73 Mb

Chr 18: 35.72 - 35.74 Mb

Pubmed search

[1]

[2]

Poly(A) binding protein interacting protein 2, also known as PAIP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PAIP2 poly(A) binding protein interacting protein 2.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Khaleghpour K, Svitkin YV, Craig AW, et al. (2001). "Translational repression by a novel partner of human poly(A) binding protein, Paip2.". Mol. Cell 7 (1): 205–16. PMID 11172725.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Kozlov G, Trempe JF, Khaleghpour K, et al. (2001). "Structure and function of the C-terminal PABC domain of human poly(A)-binding protein.". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4409–13. doi:10.1073/pnas.071024998. PMID 11287632.
Khaleghpour K, Kahvejian A, De Crescenzo G, et al. (2001). "Dual interactions of the translational repressor Paip2 with poly(A) binding protein.". Mol. Cell. Biol. 21 (15): 5200–13. doi:10.1128/MCB.21.15.5200-5213.2001. PMID 11438674.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gouyon F, Onesto C, Dalet V, et al. (2003). "Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.". Biochem. J. 375 (Pt 1): 167–74. doi:10.1042/BJ20030661. PMID 12820898.
Onesto C, Berra E, Grépin R, Pagès G (2004). "Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.". J. Biol. Chem. 279 (33): 34217–26. doi:10.1074/jbc.M400219200. PMID 15175342.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Yoshida M, Yoshida K, Kozlov G, et al. (2006). "Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2.". EMBO J. 25 (9): 1934–44. doi:10.1038/sj.emboj.7601079. PMID 16601676.
Berlanga JJ, Baass A, Sonenberg N (2006). "Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.". RNA 12 (8): 1556–68. doi:10.1261/rna.106506. PMID 16804161.