PADI3

From Wikipedia, the free encyclopedia

Peptidyl arginine deiminase, type III

Identifiers

PADI3; MGC126307; MGC126308; PAD3; PDI3

External IDs

OMIM: 606755 MGI: 1338891 HomoloGene: 7882

Gene ontology
Molecular Function:	• protein-arginine deiminase activity • calcium ion binding • hydrolase activity
Biological Process:	• protein modification process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016233 (mRNA)
NP_057317 (protein)

NM_011060 (mRNA)
NP_035190 (protein)

Location

Chr 1: 17.45 - 17.48 Mb

Chr 4: 140.06 - 140.08 Mb

Pubmed search

[1]

[2]

Peptidyl arginine deiminase, type III, also known as PADI3, is a human gene.^[1]

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.^[1]

[edit] References

^ ^a ^b Entrez Gene: PADI3 peptidyl arginine deiminase, type III.

[edit] Further reading

Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn GJ (2004). "PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.". Bioessays 25 (11): 1106–18. doi:10.1002/bies.10357. PMID 14579251.
Chavanas S, Méchin MC, Nachat R, et al. (2006). "Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.". J. Dermatol. Sci. 44 (2): 63–72. doi:10.1016/j.jdermsci.2006.07.004. PMID 16973334.
Rus'd AA, Ikejiri Y, Ono H, et al. (1999). "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.". Eur. J. Biochem. 259 (3): 660–9. PMID 10092850.
Kanno T, Kawada A, Yamanouchi J, et al. (2000). "Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin.". J. Invest. Dermatol. 115 (5): 813–23. doi:10.1046/j.1523-1747.2000.00131.x. PMID 11069618.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chavanas S, Méchin MC, Takahara H, et al. (2004). "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.". Gene 330: 19–27. doi:10.1016/j.gene.2003.12.038. PMID 15087120.
Iida A, Nakamura Y (2004). "Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13.". J. Hum. Genet. 49 (7): 387–90. doi:10.1007/s10038-004-0156-1. PMID 15150696.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nachat R, Méchin MC, Takahara H, et al. (2005). "Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.". J. Invest. Dermatol. 124 (2): 384–93. doi:10.1111/j.0022-202X.2004.23568.x. PMID 15675958.
Méchin MC, Enji M, Nachat R, et al. (2005). "The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.". Cell. Mol. Life Sci. 62 (17): 1984–95. doi:10.1007/s00018-005-5196-y. PMID 16091842.
Dong S, Kanno T, Yamaki A, et al. (2006). "NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes.". Biochem. J. 397 (3): 449–59. doi:10.1042/BJ20051939. PMID 16671893.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.