PACSIN3

From Wikipedia, the free encyclopedia

Protein kinase C and casein kinase substrate in neurons 3

Identifiers

External IDs

OMIM: 606513 MGI: 1891410 HomoloGene: 41117

Gene ontology
Molecular Function:	• cytoskeletal protein binding • enzyme binding
Cellular Component:	• cytoplasm
Biological Process:	• endocytosis • negative regulation of endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016223 (mRNA)
NP_057307 (protein)

NM_028733 (mRNA)
NP_083009 (protein)

Location

Chr 11: 47.16 - 47.16 Mb

Chr 2: 91.06 - 91.07 Mb

Pubmed search

[1]

[2]

Protein kinase C and casein kinase substrate in neurons 3, also known as PACSIN3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PACSIN3 protein kinase C and casein kinase substrate in neurons 3.

[edit] Further reading

Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.". J. Biol. Chem. 274 (44): 31693-9. PMID 10531379.
Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.". J. Cell. Sci. 113 Pt 24: 4511-21. PMID 11082044.
Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.". Gene 262 (1-2): 199-205. PMID 11179684.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mori S, Tanaka M, Nanba D, et al. (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.". J. Biol. Chem. 278 (46): 46029-34. doi:10.1074/jbc.M306393200. PMID 12952982.
Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions.". J. Biol. Chem. 279 (11): 10756-64. doi:10.1074/jbc.M309909200. PMID 14679214.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Onodera Y, Hashimoto S, Hashimoto A, et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.". EMBO J. 24 (5): 963-73. doi:10.1038/sj.emboj.7600588. PMID 15719014.
Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.". J. Biol. Chem. 281 (27): 18753-62. doi:10.1074/jbc.M602452200. PMID 16627472.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.