PACSIN1

From Wikipedia, the free encyclopedia

Protein kinase C and casein kinase substrate in neurons 1

Identifiers

PACSIN1; KIAA1379; SDPI

External IDs

OMIM: 606512 MGI: 1345181 HomoloGene: 22674

Gene ontology
Molecular Function:	• protein kinase activity • cytoskeletal protein binding • kinase activity
Cellular Component:	• cytoplasm • COPI-coated vesicle
Biological Process:	• endocytosis • negative regulation of endocytosis

Orthologs

Human

Mouse

Refseq

NM_020804 (mRNA)
NP_065855 (protein)

NM_011861 (mRNA)
NP_035991 (protein)

Location

Chr 6: 34.54 - 34.61 Mb

Chr 17: 27.38 - 27.44 Mb

Pubmed search

[1]

[2]

Protein kinase C and casein kinase substrate in neurons 1, also known as PACSIN1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PACSIN1 protein kinase C and casein kinase substrate in neurons 1.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Qualmann B, Roos J, DiGregorio PJ, Kelly RB (1999). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.". Mol. Biol. Cell 10 (2): 501-13. PMID 9950691.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.". J. Cell. Sci. 113 Pt 24: 4511-21. PMID 11082044.
Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.". Gene 262 (1-2): 199-205. PMID 11179684.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.". J. Mol. Biol. 307 (5): 1329-39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Wasiak S, Quinn CC, Ritter B, et al. (2001). "The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton.". J. Biol. Chem. 276 (28): 26622-8. doi:10.1074/jbc.M100591200. PMID 11352907.
Modregger J, DiProspero NA, Charles V, et al. (2003). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains.". Hum. Mol. Genet. 11 (21): 2547-58. PMID 12354780.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.". J. Biol. Chem. 279 (38): 40091-9. doi:10.1074/jbc.M404899200. PMID 15252009.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.". J. Biol. Chem. 281 (27): 18753-62. doi:10.1074/jbc.M602452200. PMID 16627472.