PACS1

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Phosphofurin acidic cluster sorting protein 1
Identifiers
Symbol(s) PACS1; FLJ10209; KIAA1175
External IDs OMIM: 607492 MGI: 1277113 HomoloGene: 9970
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55690 107975
Ensembl ENSG00000175115 ENSMUSG00000024855
Uniprot Q6VY07 Q3TAB8
Refseq NM_018026 (mRNA)
NP_060496 (protein)		 NM_153129 (mRNA)
NP_694769 (protein)
Location Chr 11: 65.59 - 65.77 Mb Chr 19: 5.13 - 5.27 Mb
Pubmed search [1] [2]

Phosphofurin acidic cluster sorting protein 1, also known as PACS1, is a human gene.[1]

This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.[1]

[edit] References

  1. ^ a b Entrez Gene: PACS1 phosphofurin acidic cluster sorting protein 1.

[edit] Further reading

  • Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741. 
  • Leavitt SA, SchOn A, Klein JC, et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.". Curr. Protein Pept. Sci. 5 (1): 1–8. PMID 14965316. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726. 
  • Wan L, Molloy SS, Thomas L, et al. (1998). "PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization.". Cell 94 (2): 205–16. PMID 9695949. 
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. PMID 10574461. 
  • Piguet V, Wan L, Borel C, et al. (2000). "HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.". Nat. Cell Biol. 2 (3): 163–7. doi:10.1038/35004038. PMID 10707087. 
  • Crump CM, Xiang Y, Thomas L, et al. (2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.". EMBO J. 20 (9): 2191–201. doi:10.1093/emboj/20.9.2191. PMID 11331585. 
  • Williams M, Roeth JF, Kasper MR, et al. (2002). "Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking.". J. Virol. 76 (23): 12173–84. PMID 12414957. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Blagoveshchenskaya AD, Thomas L, Feliciangeli SF, et al. (2003). "HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.". Cell 111 (6): 853–66. PMID 12526811. 
  • Stove V, Naessens E, Stove C, et al. (2003). "Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development.". Blood 102 (8): 2925–32. doi:10.1182/blood-2003-03-0833. PMID 12855553. 
  • Hinners I, Wendler F, Fei H, et al. (2004). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1.". EMBO Rep. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMID 14608369. 
  • Scott GK, Gu F, Crump CM, et al. (2004). "The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.". EMBO J. 22 (23): 6234–44. doi:10.1093/emboj/cdg596. PMID 14633983. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Köttgen M, Benzing T, Simmen T, et al. (2005). "Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.". EMBO J. 24 (4): 705–16. doi:10.1038/sj.emboj.7600566. PMID 15692563. 
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