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| p27 cis-regulatory element |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Predicted; PFOLD; Moxon SJ |
| Seed alignment: |
12006670 |
| Avg length: |
58.3 nucleotides |
| Avg identity: |
92% |
|
The p27 cis-regulatory element is a structured G/C rich RNA element located in the 5' UTR of p27 mRNA. This element contributes to cell cycle regulated translation and when deleted leads to a 50% drop in regulation. The element is thought to be able to form several different structures with similar free energy. It has been suggested that proteins may only bind to a specific structure thus conformational changes could regulate translation.[1]
[edit] References
- ^ Gopfert, U; Kullmann M, Hengst L (2003). "Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF". Hum Mol Genet 12: 1767–1779. doi:10.1093/hmg/ddg177. PMID 12837699.
[edit] External links
